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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis.
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Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis.

机译：大豆摄入量和内分泌相关妇科癌症的风险：一项荟萃分析。

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BACKGROUND: Epidemiology studies have reported associations between soy intake and the risk of endocrine-related gynaecological cancers. However, to date there have been no quantitative meta-analyses reported regarding this topic. OBJECTIVES: We investigated the quantitative associations between soy food intake and the risk of endometrial cancer and ovarian cancer by a meta-analysis of case-control studies and cohort studies. SEARCH STRATEGY: We searched MEDLINE (PubMed), EMBASE and the Cochrane Library during October 2008 using common keywords related to soy intake and endometrial or ovarian cancer. Two evaluators independently reviewed and selected articles, based on predetermined selection criteria. SELECTION CRITERIA: Included studies met all of the following criteria: (1) a case-control study or cohort study (to date, no randomized controlled trials have been reported); (2) investigated the associations between 'soy or soy product intake' and 'endometrial cancer' or 'ovarian cancer'; (3) reported outcome measures with adjusted odds ratios (OR) or relative risks (RR) and 95% confidence intervals (CI). DATA COLLECTION AND ANALYSIS: We investigated the associations between the overall soy intake (highest versus lowest intake) and the risk of endocrine-related gynaecological cancers (endometrial or ovarian cancer) as the main analysis. We also performed subgroup analyses by type of cancer (endometrial or ovarian), type of study design (case-control or cohort) and type of soy intake (soy foods or soy constituents). MAIN RESULTS: Out of 477 articles that met our initial criteria, a total of seven epidemiology studies consisting of five case-control studies and two cohort studies were included in the final analyses. Compared with the lowest soy intake, the OR for the highest soy intake was 0.61 (95% CI, 0.53-0.72) of all endocrine-related cancers among seven studies; 0.70 for endometrial cancer (95% CI, 0.57-0.86) and 0.52 for ovarian cancer (95% CI, 0.42-0.66) in the fixed-effects meta-analyses. The subgroup analyses by study design showed similar findings among the case-control studies (OR, 0.62; 95% CI, 0.53-0.73) and the cohort studies (OR, 0.57; 95% CI, 0.36-0.90). AUTHOR'S CONCLUSIONS: The results of the current study showed protective effects of soy intake on the risk for endocrine-related gynaecological cancers. Additional larger prospective studies are now needed.
机译：背景：流行病学研究报告了大豆摄入量与内分泌相关妇科癌症风险之间的关联。但是，迄今为止，尚未报告有关该主题的定量荟萃分析。目的：我们通过病例对照研究和队列研究的荟萃分析，研究了大豆食品摄入量与子宫内膜癌和卵巢癌风险之间的定量关系。搜索策略：我们在2008年10月期间使用与大豆摄入量和子宫内膜或卵巢癌相关的常见关键字搜索了MEDLINE（PubMed），EMBASE和Cochrane库。两名评估员根据预定的选择标准独立审查和选择了商品。选择标准：纳入的研究符合以下所有标准：（1）病例对照研究或队列研究（迄今为止，尚无随机对照试验的报道）; （2）研究了“大豆或大豆制品摄入量”与“子宫内膜癌”或“卵巢癌”之间的关系; （3）报告了具有调整后的优势比（OR）或相对风险（RR）和95％置信区间（CI）的结果指标。数据收集和分析：我们主要研究了大豆总摄入量（最高摄入量与最低摄入量）与内分泌相关妇科癌症（子宫内膜癌或卵巢癌）风险之间的关系。我们还按癌症类型（子宫内膜或卵巢），研究设计类型（病例对照或队列）和大豆摄入类型（大豆食品或大豆成分）进行了亚组分析。主要结果：在符合我们最初标准的477篇文章中，最终分析中共包括7项流行病学研究，其中包括5例病例对照研究和2项队列研究。与最低大豆摄入量相比，七项研究中所有与内分泌有关的癌症的最高大豆摄入量的OR为0.61（95％CI，0.53-0.72）;在固定效应荟萃分析中，子宫内膜癌为0.70（95％CI，0.57-0.86），卵巢癌为0.52（95％CI，0.42-0.66）。通过研究设计进行的亚组分析显示，在病例对照研究（OR为0.62; 95％CI为0.53-0.73）和同类研究中（OR为0.57; 95％CI为0.36-0.90），发现相似。作者的结论：当前研究的结果表明，摄入大豆对内分泌相关妇科癌症的风险具有保护作用。现在需要更多的前瞻性研究。

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