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首页> 外文期刊>Autoimmune diseases >Silent Burdens in Disease: Fatigue and Depression in SLE.
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Silent Burdens in Disease: Fatigue and Depression in SLE.

机译：疾病中的沉默沉重：SLE的疲劳和抑郁。

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摘要

At a time when health is being recognized as more than just avoiding death, age and comorbidity are becoming increasingly important aspects of chronic disease. Systemic Lupus Erythematous (SLE) is probably one of the best paradigms of modern chronic disease, sitting at the crossroads of numerous somatic health problems, immune activation, depression, pain, and fatigue. One hundred forty-eight female participants were enrolled in the present study: 50 diagnosed with SLE, 45 with major depressive disorder (MDD), and 53 age-matched controls. Statistically significant lower scores in quality-of-life dimensions related to physical impairment were found in SLE. Patients with MDD presented significant levels of pain, reduced physical summary component (PSC), and general health scores different from healthy controls. Fatigue was reported in 90% of women with SLE and 77.8% of the MDD patients in contrast with 39.6% in the control group. Significant correlations were seen among fatigue severity, age, and educational level in SLE. From our own previous work and more recent work on the association of immune activation and depression, unexplained fatigue in SLE may signify an early sign of immune activation flare-up. The search for cytokine markers should perhaps be extended to fatigue in SLE.
机译：在避免死亡的情况下，在健康被认为是慢性疾病的年龄和合并症的时间变得越来越重要。 Systemic Lupus eryhematous（SLE）可能是现代慢性病的最佳范式之一，坐在众多体细胞健康问题，免疫激活，抑郁，疼痛和疲劳的十字路口。在本研究中注册了一百四十八位女性参与者：50诊断为SLE，45个，具有重大抑郁症（MDD）和53次匹配的对照。在SLE中发现与物理损伤有关的寿命质量尺寸的统计学上显着的较低分数。 MDD患者提出了显着的疼痛，减少了物理摘要组成部分（PSC），以及与健康对照不同的一般健康评分。在90％的妇女中报道了疲劳，其中77.8％的MDD患者，对照组39.6％。 SLE中疲劳严重程度，年龄和教育水平之间观察到显着相关性。从我们以前的工作和更新的免疫激活和抑郁协定的工作中的更新工作，无原因的SLE中的疲劳可能意味着免疫激活爆发的早期迹象。寻找细胞因子标记，也许应该扩展到SLE中的疲劳。

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  • 来源
    《Autoimmune diseases》 |2014年第1期|共1页
  • 作者

    Fonseca R;

  • 作者单位

    Department of Clinical Neurosciences and Mental Health Faculty of Medicine University of Porto;

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  • 正文语种 eng
  • 中图分类 内科学;
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