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首页> 外文期刊>Autoimmunity reviews >Breast cancer in systemic sclerosis: Results of a cross-linkage of an Italian Rheumatologic Center and a population-based Cancer Registry and review of the literature
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Breast cancer in systemic sclerosis: Results of a cross-linkage of an Italian Rheumatologic Center and a population-based Cancer Registry and review of the literature

机译：系统性硬化症中的乳腺癌：意大利风湿病中心的交联和基于人口的癌症登记和文学审查结果结果

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摘要

Objective: Increased frequency of few types of cancer in systemic sclerosis (SSc) has been reported in the literature; in particular, breast carcinoma has been proposed as one of the most frequent malignancy in SSc patients, even though data are not univocal. The aim of the present study was to retrospectively evaluate the prevalence of breast cancer in our SSc series, compared with sex-/age-matched general population of the same geographical area, and the possible correlations with SSc features, including X-ray exposure for clinical investigations. A review of the world literature about this topic was also done. Methods: Clinical records of 318 consecutive SSc patients, 31 M and 287 F, age 51.5 ± 14.5 SD years, disease duration 10 ± 6.5 SD years, referred to our Rheumatology Unit between January 2002 and December 2012 were evaluated. Results: Twelve (3.8%) cases of breast cancer were recorded, including 11/287 females (3.8%) and 1/31 (3.2%) male patients. Considering the subgroup of 202 SSc patients resident in the Province of Modena compared with data of the local Tumor Registry, the incidence of breast cancer observed in our SSc series is significantly higher than expected (SIR 2.1; 95% interval of confidence: 1.13-3.90; p < 0.01). On the whole, the comparison between SSc patients with cancer and those without did not show any significant differences with regard to SSc clinical features, including the X-ray exposure. Of note is the relatively shorter disease duration at the time of breast cancer detection (median 2.5. years, range 1-21; disease duration of mean 10 ± 6.5 SD years in the entire cohort).The review of the literature revealed that the observed incidence of breast cancer in our case series is comparable to the few studies reporting the highest percentages of this malignancy. Conclusions: A significant increase of breast cancer incidence compared to sex-age-matched general population from the same geographic area was observed. Moreover, a close temporal relationship between SSc and breast cancer onset was found, independently from clinical, serological, and instrumental features of SSc. The possible pathogenetic link between this systemic autoimmune disease and complicating breast cancer, as well as the results of previous studies, are discussed.
机译：目的：在文献中报道了全身硬化症（SSC）中少数癌症的频率增加;特别是，乳腺癌已被提出为SSC患者中最常见的恶性肿瘤之一，即使数据不是单一的。本研究的目的是回顾性评估我们SSC系列中乳腺癌的患病率，与相同地理区域的性别/年龄匹配的一般人群相比，以及与SSC功能的可能相关性，包括X射线暴露临床调查。还完成了关于这个主题的世界文学的综述。方法：318名连续SSC患者的临床记录，31米和287岁，年龄51.5±14.5 SD年龄，疾病期限为10±6.5岁，提交2002年1月至2012年12月之间的风湿病学单位。结果：记录了12例（3.8％）乳腺癌病例，包括11/287雌性（3.8％）和1/31（3.2％）男性患者。考虑到摩德纳省的202例SSC患者的亚组与本地肿瘤登记处的数据相比，我们SSC系列中观察到的乳腺癌的发病率明显高于预期（SIR 2.1; 95％的信心间隔：1.13-3.90 ; P <0.01）。总的来说，SSC癌症患者的比较和没有表现出与SSC临床特征有关的任何显着差异，包括X射线暴露。注意是在乳腺癌检测时的疾病持续时间相对较短（中位数2.5.年，范围1-21;整个群组的疾病持续时间为10±6.5 SD岁）。审查文献透露了观察到的我们的案例系列中乳腺癌的发病率与报告这种恶性肿瘤的最高百分比的少数研究相当。结论：观察到与来自同一地理区域的性别匹配的一般人群相比，乳腺癌发病率大幅增加。此外，从SSC的临床，血清学和仪器特征中发现了SSC和乳腺癌发作之间的密切时间关系。讨论了这种全身自身免疫疾病与复杂性乳腺癌之间的可能致病联系，以及先前研究的结果。

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  • 来源
    《Autoimmunity reviews》 |2014年第2期|共6页
  • 作者

    ColaciM.; GiuggioliD.; VacchiC.; LumettiF.; IachettaF.; MarcheselliL.; FedericoM.; FerriC.;

  • 作者单位

    Rheumatology Unit University of Modena and Reggio Emilia Medical School Azienda Ospedaliero;

    Rheumatology Unit University of Modena and Reggio Emilia Medical School Azienda Ospedaliero;

    Rheumatology Unit University of Modena and Reggio Emilia Medical School Azienda Ospedaliero;

    Rheumatology Unit University of Modena and Reggio Emilia Medical School Azienda Ospedaliero;

    Modena Cancer Registry Department of Diagnostic Medicine Clinical and Public Health University;

    Modena Cancer Registry Department of Diagnostic Medicine Clinical and Public Health University;

    Modena Cancer Registry Department of Diagnostic Medicine Clinical and Public Health University;

    Rheumatology Unit University of Modena and Reggio Emilia Medical School Azienda Ospedaliero;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    Breast cancer; Scleroderma; Systemic sclerosis;

    机译：乳腺癌;硬皮病;系统性硬化症;

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