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首页> 外文期刊>Acta Radiologica >Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals.
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals.

机译：动态对比增强磁共振成像（DCE-MRI）和健康个体骨髓的弥散加权成像。

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Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) displays microcirculation and permeability by application of contrast-media and diffusion-weighted imaging (DWI) is a tool for quantification of cellularity in the investigated area. Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies. Purpose To investigated the influence of age, sex, and localization of the investigated region on findings of DCE-MRI and DWI. Material and Methods DCE-MRI-parameters amplitude A and exchange rate constant kep as well as the DWI-parameter ADC of the bone marrow of the lumbar vertebral column of 30 healthy individuals covering the typical range of age of tumor patients were evaluated. ADC was calculated using b=0 and a maximal b value of either 400 or 750 s/mm(2). Results Amplitude A of DCE-MRI decreased with age (P = 0.01) and amplitude A, exchange rate constant kep as well as ADC based on b = 400 s/mm(2) and b = 750 s/mm(2,) respectively, decreased significantly from the first to the fifth lumbar vertebra with P = 0.02, P = 0.05, P = 0.003, and P = 0.002, respectively. Conclusion Quantitative parameters of functional imaging techniques in bone marrow are influenced by the age of the examined individual and the anatomical location of the investigated region.
机译：背景技术动态对比增强磁共振成像（DCE-MRI）通过应用对比介质显示微循环和通透性，而弥散加权成像（DWI）是定量研究区域中细胞数量的工具。最近发表的例子涵盖了乳腺癌，中枢神经系统肿瘤，头颈癌，胃肠道癌，前列腺癌以及血液系统恶性肿瘤。目的研究年龄，性别和研究区域的局部性对DCE-MRI和DWI结果的影响。材料和方法评估了30名覆盖典型肿瘤患者年龄范围的健康个体的腰椎脊柱骨髓的DCE-MRI参数振幅A和交换速率常数kep以及DWI参数ADC。 ADC使用b = 0且最大b值为400或750 s / mm（2）计算得出。结果DCE-MRI的振幅A随年龄（P = 0.01）和振幅A，交换速率常数kep以及基于b = 400 s / mm（2）和b = 750 s / mm（2，）的ADC而降低，从第一个到第五个腰椎显着下降，分别为P = 0.02，P = 0.05，P = 0.003和P = 0.002。结论骨髓功能成像技术的定量参数受所检查个体的年龄和所研究区域的解剖位置的影响。

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