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首页> 外文期刊>Acta Radiologica >The multislice CT findings of renal carcinoma associated with XP11.2 translocation/TFE gene fusion and collecting duct carcinoma.
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The multislice CT findings of renal carcinoma associated with XP11.2 translocation/TFE gene fusion and collecting duct carcinoma.

机译：与XP11.2易位/ TFE基因融合和收集导管癌相关的肾癌的多层CT表现。

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摘要

Renal cell carcinoma associated with Xp11.2 translocation and TFE gene fusion (Xp11.2/TFE RCC), and collecting duct carcinoma (CDC) are uncommon subtypes of renal cell carcinomas.To investigate the multislice CT (MSCT) characteristics of these two tumor types.Nine patients with Xp11.2/TFE RCC and 10 patients with CDC were studied retrospectively. MSCT was undertaken to investigate differences in tumor characteristics and enhancement patterns.All patients had single tumors centered in the renal medulla. Two patients with each tumor type had lymph node involvement and there was a single case of hepatic metastasis (Xp11.2/TFE RCC). The mean tumor diameter of Xp11.2/TFE RCC tumors was significantly larger than for CDC tumors. Two patients with Xp11.2/TFE RCC had cystic components as did eight patients with CDC (P < 0.05). Calcifications were present in six patients, each with CDC. Clear tumor boundaries were visible in two patients with CDC and in nine with Xp11.2/TFE RCC (P < 0.05). The density of Xp11.2/TFE RCC tumors was greater than that of CDC tumors, normal renal cortex, or medulla on unenhanced CT. Enhancement was higher with Xp11.2/TFE RCC than with CDC tumors during all phases. Xp11.2/TFE RCC enhancement was higher than in the renal medulla during cortical and medullary phase but lower than in normal renal medulla during the delayed phase. CDC tumor enhancement was lower than that for normal renal medulla during all enhanced phases.Both tumor types originated from the renal medulla. Distinguishing features included density on unenhanced CT, enhancement patterns, and capsule signs. Identifying these differences may aid diagnosis.
机译：与Xp11.2易位和TFE基因融合相关的肾细胞癌（Xp11.2 / TFE RCC）和收集导管癌（CDC）是肾细胞癌的罕见亚型。研究这两种肿瘤的多层CT（MSCT）特征回顾性研究了9例Xp11.2 / TFE RCC患者和10例CDC患者。进行MSCT检查以研究肿瘤特征和增强模式的差异。所有患者均以肾髓质为中心的单个肿瘤。每种肿瘤类型的两名患者都有淋巴结受累，只有一例肝转移（Xp11.2 / TFE RCC）。 Xp11.2 / TFE RCC肿瘤的平均肿瘤直径显着大于CDC肿瘤。 Xp11.2 / TFE RCC的两名患者具有囊性成分，八名CDC的患者具有囊性成分（P <0.05）。在六名患有CDC的患者中出现钙化。在2例CDC患者和9例Xp11.2 / TFE RCC患者中可见清晰的肿瘤边界（P <0.05）。 Xp11.2 / TFE RCC肿瘤的密度大于CDC肿瘤，正常肾皮质或未加CT的髓质。在所有阶段，Xp11.2 / TFE RCC的增强作用均高于CDC肿瘤。 Xp11.2 / TFE RCC增强在皮质和髓质期高于肾髓质，但在延迟期低于正常肾髓质。在所有增强阶段，CDC肿瘤的增强均低于正常肾髓质。两种肿瘤类型均起源于肾髓质。显着特征包括未增强CT的密度，增强模式和囊征。识别这些差异可能有助于诊断。

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