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MRI features of intraductal papilloma of the breast: sheep in wolf's clothing?

机译:乳腺导管内乳头状瘤的MRI特征:穿羊皮的狼?

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Background Intraductal papillomas often present as small, smooth masses, dilated ducts or microcalcifications at mammography and as smooth, hypoechoic masses at sonography. At magnetic resonance imaging (MRI), intraductal papillomas often present as small smooth masses, however, often with strong enhancement with type 2 or 3 time intensity curves. The result of the MR analysis is therefore not infrequently inconclusive in order to characterize the mass as benign or malignant. Purpose To characterize the appearance of intraductal papillomas of the breast at MRI, and determine whether the application of diagnostic rules described in literature could contribute to correctly classifying the lesions as benign. Material and Methods Twenty patients with histologically proven intraductal papillomas were included. Two radiologists independently reviewed the MR images of the breast. The BI-RADS((R)) nomenclature was used to describe morphology and contrast-enhancement kinetics. Interobserver agreement in the interpretation of the MR images by the two investigators was performed. Kappa coefficient was calculated as index for the level of agreement. Subsequently, three sets of diagnostic rules, including the Gottinger score described by Fischer and the interpretation flowcharts according to Kinkel and to Tozaki were applied to characterize whether a biopsy should be recommended or not. Results All papillomas presented as masses on dynamic contrast-enhanced MRI. Only five papillomas showed a round, oval, or lobulated shape combined with smooth margins and continuous rise of the time intensity curve. Using the Gottingen score, biopsy would be recommended in 16 patients. Based on the interpretation flowcharts of Kinkel and of Tozaki, an additional 13 and 10 papillomas, respectively, were correctly classified as benign. Dilated ducts were visible in 10 patients. The interobserver agreement was good or excellent for all included variables. Conclusion Including systematic analysis of breast MRI to the diagnostic protocol and interpreting the images according to predetermined diagnostic rules, most solitary intraductal papillomas of the breast may be correctly characterized as benign.
机译:背景技术导管内乳头状瘤通常在乳腺X线检查时表现为小而光滑的肿块,扩张的导管或微钙化,在超声检查时常表现为光滑,低回声的肿块。在磁共振成像(MRI)时,导管内乳头状瘤通常表现为小的平滑肿块,但是通常随着2型或3型时间强度曲线而明显增强。因此,为了将肿块表征为良性或恶性,MR分析的结果并非总是不确定的。目的在MRI上表征乳腺导管内乳头状瘤的外观,并确定文献中描述的诊断规则的应用是否有助于正确地将病变分类为良性。材料和方法纳入20例经组织学证实为导管内乳头状瘤的患者。两名放射科医生独立检查了乳房的MR图像。 BI-RADS(R)命名法用于描述形态和对比度增强动力学。两名研究人员在解释MR图像时达成了观察员之间的协议。计算卡伯系数作为一致性水平的指标。随后,应用了三套诊断规则,包括由Fischer描述的Gottinger评分以及根据Kinkel和Tozaki的解释流程图,以表征是否应建议进行活检。结果在动态对比增强MRI上所有乳头状瘤均呈肿块状。只有五个乳头状瘤呈圆形,椭圆形或小叶状,边缘平滑,时间强度曲线持续上升。使用Gottingen评分,建议对16例患者进行活检。根据Kinkel和Tozaki的解释流程图,分别将另外的13和10个乳头状瘤正确分类为良性。 10例患者可见导管扩张。观察者之间的共识对于所有包含的变量都是好是好。结论包括对乳腺MRI进行系统分析以诊断方案,并根据预定的诊断规则对图像进行解释,大多数乳腺孤立性导管内乳头状瘤可被正确地表征为良性。

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