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首页> 外文期刊>Acta Radiologica >Biexponential analysis of diffusion-weighted imaging: comparison of three different calculation methods in transplanted kidneys
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Biexponential analysis of diffusion-weighted imaging: comparison of three different calculation methods in transplanted kidneys

机译：扩散加权成像的双指数分析：移植肾脏中三种不同计算方法的比较

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Background: Biexponential analysis has been used increasingly to obtain contributions of both diffusion and micro-perfusion to the signal decay in diffusion-weighted imaging DWI of different parts of the body. Purpose: To compare biexponential diffusion parameters of transplanted kidneys obtained with three different calculation methods.Material and Methods: DWI was acquired in 15 renal allograft recipients (eight men, seven women; mean age, 52.4± 14.3 years) using a paracoronal EPI sequence with 16 b-values (b = 0-750s/mm~2) and six averages at I.5T. No respiratory gating was used. Three different calculation methods were used for the calculation of biexponential diffusion parameters: F_p, ADCp, and ADC_D were calculated without fixing any parameter a priori (calculation method I); ADCp was fixed to 12.0 mum~2/ms, whereas F_p and ADC_D were calculated using the biexponential model (calculation method 2); multistep approach with monoexponential fitting of the high b-value portion (b >= 250 s/mm~2) for determination of ADC_D and assessment of the low b intercept for determination of F_p (calculation method 3). For quantitative analysis, ROI measurements were performed on the according parameter maps. Results: Mean ADC_D values of the renal cortex using calculation method I were significantly lower than using calculation methods 2 and 3 (P<0.001). There was a significant correlation between calculation methods I and 2 (r = 0.69 (P< 0.005) and calculation methods 1 and 3 (r = 0.59; P<0.05) as well as calculation methods 2 and 3 (r = 0.98; P<0.001). Mean F_p values of the renal cortex were higher with calculation method I than with calculation methods 2 and 3 (P < 0.001). For F_p, only the correlation between calculation methods 2 and 3 was significant (r = 0.98; P < 0.001). Conclusion: Biexponential diffusion parameters differ significantly depending on the calculation methods used for their calculation.
机译：背景：双指数分析已越来越多地用于获得扩散和微灌注对人体不同部位的扩散加权成像DWI中信号衰减的贡献。目的：比较三种不同计算方法获得的移植肾的双指数扩散参数。材料与方法：DWI是在15名同种异体肾移植受者中获得的（8名男性，7名女性;平均年龄为52.4±14.3岁），使用冠状旁腺EPI序列I.5T有16个b值（b = 0-750s / mm〜2）和6个平均值。没有使用呼吸门控。三种不同的计算方法用于计算双指数扩散参数：F_p，ADCp和ADC_D的计算无需事先确定任何参数（计算方法I）; ADCp固定为12.0μm〜2 / ms，而F_p和ADC_D使用双指数模型计算（计算方法2）;多步法，对b值高的部分（b> = 250 s / mm〜2）进行单指数拟合，以确定ADC_D，对b截距的低值进行评估，以确定F_p（计算方法3）。为了进行定量分析，在相应的参数图上进行了ROI测量。结果：使用计算方法I的平均肾皮质ADC_D值明显低于使用计算方法2和3的平均P_0.001（P <0.001）。计算方法I和2（r = 0.69（P <0.005）与计算方法1和3（r = 0.59; P <0.05）以及计算方法2和3（r = 0.98; P < 0.001）。计算方法I的平均肾皮质F_p值高于计算方法2和3（P <0.001）。对于F_p，只有计算方法2和3之间的相关性显着（r = 0.98; P <0.001）。 0.001）结论：双指数扩散参数根据计算所用的计算方法而有很大差异。

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