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首页> 外文期刊>Avian Diseases >Efficacy of Tylosin and Tilmicosin Against Experimental Mycoplasma gallisepticum Infection in Chickens
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Efficacy of Tylosin and Tilmicosin Against Experimental Mycoplasma gallisepticum Infection in Chickens

机译：噻吩和蒂米松对鸡实验支原体脑腹膜感染的疗效

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Mycoplasma gallisepticum, the cause of chronic respiratory disease, remains one of the most important pathogens in the poultry industry. Controlling the impact of this disease is done by eradication of positive breeder flocks or by vaccination and medication. Tylosin and tilmicosin are often used in medication programs. However, recent data on the in vivo efficacy of these macrolide antibiotics are scarce. Therefore, two dose titration studies were conducted using a recently isolated M. gallisepticum strain belonging to the wild-type population with regard to its tilmicosin and tylosin minimal inhibitory concentration. In a first trial, broilers were infected with M. gallisepticum and treated with 10 or 20 mg tilmicosin/kg body weight (BW) in the drinking water for five successive days. In a second trial, broilers were infected with M. gallisepticum and treated with 35 or 100 mg tylosin/kg BW in the drinking water for five successive days. Clinical scoring of respiratory signs, macroscopic scoring of respiratory tract lesions, M. gallisepticum isolation from the respiratory organs, weight gain, and mortality were monitored for efficacy evaluation. All tylosin and tilmicosin treatments significantly reduced the course of clinical respiratory disease, macroscopic lesions in the respiratory organs, and M. gallisepticum numbers in the respiratory tract and obtained higher weight gains compared with the Mycoplasma-infected untreated control group. A treatment of 100 mg tylosin/kg daily for 5 days was not more clinically efficacious than the dosage of 35 mg tylosin/kg daily for 5 days. At final necropsy, in animals treated with 20 mg/kg BW tilmicosin, significantly fewer respiratory tract lesions were present than in the animals treated with 10 mg/kg BW tilmicosin. Therefore, when tilmicosin is used to treat clinical outbreaks of M. gallisepticum in broilers, a dosing scheme of 20 mg tilmicosin/kg BW for five successive days seems to be the most recommended scheme.
机译：慢性呼吸道疾病的病因支原体Gallisepticum仍然是家禽行业中最重要的病原体之一。通过消除阳性饲养群或疫苗接种和药物来控制这种疾病的影响。泰罗辛和蒂米康辛通常用于药物计划。然而，最近这些大环内德抗生素的体内疗效的数据很少。因此，使用最近分离的M. Gallisepticum菌株进行两种剂量滴定研究，该研究属于野生型群体，关于其TilmicoSin和Tylosin最小抑制浓度。在第一次试验中，肉鸡被M. gallisepticum感染，并在饮用水中用10或20mg Tilmicosin / kg体重（BW）进行了五个连续日期。在第二次试验中，肉鸡感染了M. gallisepticum，并在饮用水中用35或100mg Tylosin / Kg BW治疗，连续五天。呼吸症患者的临床评分，呼吸道病变的宏观评分，监测呼吸道器官，体重增加和死亡率的脑腹部分离，疗效评估。所有替辛辛和蒂米啶素治疗都显着降低了临床呼吸道疾病的过程，呼吸道器官中的宏观病变，与呼吸道中的M. Gallisepticum数，与支原体感染的未处理对照组相比较高的重量增加。每天5天治疗100毫克Tylosin / kg，而不是每天35mg Tylosin / kg的剂量术临床效果。在最终尸检时，在用20mg / kg倾斜的动物处理的动物中，存在呼吸道损伤的显着较少，而不是用10mg / kg bw tilmicosin处理的动物。因此，当Tilmicosin用于治疗肉鸡中的脑嗜含量的临床爆发时，连续五天的20mg Tilmicosin / Kg BW的给药方案似乎是最推荐的计划。

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