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首页> 外文期刊>Avian Diseases >Infectious Bronchitis Virus Vaccination at Day 1 of Age Further Limits Cross Protection
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Infectious Bronchitis Virus Vaccination at Day 1 of Age Further Limits Cross Protection

机译：年龄第1天的感染性支气管炎病毒疫苗接种进一步限制了交叉保护

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Cross-protection and immune responses elicited by infectious bronchitis virus (IBV) vaccination on Day 1 of age or at later rime points were examined. Specific-pathogen-free chickens were vaccinated with a Massachusetts-type vaccine and heterologous challenge was performed with an Arkansas (Ark) -type virulent strain. In Trial 1, chickens vaccinated on Day 1 or Day 10 of age were challenged 21 days after vaccination. Analysis of tracheal histopathology and viral load demonstrated less cross protection when vaccination was performed on Day 1 of age. In Trial 2, chickens were vaccinated on Day 1 or Day 14 of age. A somewhat stronger systemic antibody response to IBV was detected in chickens vaccinated at 14 days of age. In addition, avidity of antibodies to Ark-type S 1 protein elicited by vaccination at 14 days of age was greater. Differences in immune-cell populations in the Harderian gland (HG) observed at the time of sampling (35 days following vaccination) between chickens vaccinated at 1 day or 14 days of age indicated greater, rather than reduced, immune activity in the chickens vaccinated at 1 day of age. These differences are, perhaps, a result of the higher levels of persisting vaccine virus observed in the younger chickens. Both nonvaccinated/challenged groups showed significantly higher (P 0.05) proportions of B cells and CD8(+) T cells 7 days after challenge than age-matched vaccinated/challenged groups or age-matched nonvaccinated/nonchallenged control groups. These results indicate infiltration and/or expansion of B cells and CD8(+) cells in HGs following challenge of nonvaccinated chickens. A fortuitous finding was that the more immature immune system of chickens vaccinated at 1 day of age was less effective at clearing vaccine virus after vaccination. Collectively, the current results indicate that IBV vaccination at 1 day of age can decrease the potential for heterologous cross protection compared with vaccination at least 10 days after hatch. A lower level of antibody affinity maturation likely contributes to decreased cross protection.
机译：研究了感染性支气管炎病毒（IBV）疫苗接种的交叉保护和免疫应答，或在年龄的第1天或以后的霜点处进行疫苗接种。用Massachusetts型疫苗接种特定病原体鸡，并用阿肯色州（ARK）型毒性菌株进行异源攻击。在试验1中，在疫苗接种后21天挑战时期或第10天疫苗的鸡。气管组织病理学和病毒载体分析在年龄第1天进行疫苗接种时表现出较少的交叉保护。在试验2中，鸡在年龄的1或第14天接种疫苗。在14天疫苗的鸡中检测到对IBV的较强的全身抗体反应。此外，通过在14天疫苗接种引发的ARK型S1蛋白的抗体的亲和性更大。在1天或14天疫苗接种的鸡接种鸡的鸡疫苗（疫苗接种后35天）观察到的硬质腺体（Hg）中的差异，而不是在接种的鸡中的鸡中的免疫活性1天。这些差异可能是在年轻鸡中观察到更高水平的持续性疫苗病毒的结果。在攻击之后，非过息/攻击性的基团两种非过息/攻击性的基团显示出比年龄匹配的接种/攻击群体或年龄匹配的非累积/非挑战对照组的攻击后7天的B细胞和CD8（+）T细胞的比例显着更高（P <0.05）比例。这些结果表明在非过妇药攻击后HGS中B细胞和CD8（+）细胞的渗透和/或扩增。偶然的发现是，在疫苗接种后，在1天疫苗接种疫苗的鸡免疫系统更加不成熟。总的来说，目前的结果表明，在孵化后至少10天的疫苗接种相比，1天的IBV疫苗接种可以减少异源交叉保护的可能性。较低水平的抗体亲和力成熟可能有助于减少交叉保护。

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