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首页> 外文期刊>Avian Diseases >Commercial Vaccines and Vaccination Strategies Against Infectious Laryngotracheitis: What We Have Learned and Knowledge Gaps That Remain
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Commercial Vaccines and Vaccination Strategies Against Infectious Laryngotracheitis: What We Have Learned and Knowledge Gaps That Remain

机译：商业疫苗和抗病患者的疫苗接种策略：我们所吸取的知识和留下的知识差距

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摘要

Infectious laryngotracheitis (ILT) is an upper respiratory disease of chickens, pheasants, and peafowl caused by the alphaherpesvirus Gallid alpha herpesvirus 1 (GaHV-1), commonly known as infectious laryngotracheitis virus. ILT is an acute respiratory disease characterized by dinical signs of conjunctivitis, nasal discharge, dyspnea, and lethargy. In severe forms of the disease, hemorrhagic tracheitis together with gasping, coughing, and expectoration of bloody mucus are common. The morbidity and mortality rates of the disease vary depending on the virulence of the strain circulating, the level of virus circulating in the field, and the presence of other respiratory infections. Since the identification of the disease in the 1920s, ILT continues to affect the poultry industry negatively across the globe. The disease is primarily controlled by a combination of biosecurity and vaccination. The first commercial vaccines, introduced in the late 1950s and early 1960s, were the chicken embryo origin live attenuated vaccines. The tissue culture origin vaccine was introduced in late 1970s. Recombinant viral vector ILT vaccines were first introduced in the United States in the 2000s, and now they are being used worldwide, alone or in combination with live attenuated vaccines. This review article provides a synopsis of what we have learned about vaccines and vaccination strategies used around the world and addresses knowledge gaps about the virus and host interactions that remain unknown.
机译：感染性喉部阴影炎（ILT）是鸡，雉和孔雀的上呼吸系统疾病，由Alphaherpesvirus GallidαHerpesvirus 1（Gahv-1）引起，通常称为传染性喉部炎病毒。 ILT是一种急性呼吸系统疾病，其特征在于结膜炎，鼻涕，呼吸困难和嗜睡的含量。在严重的形式的疾病中，出血性气管炎与喘气，咳嗽和血性粘液的咳痰是常见的。该疾病的发病率和死亡率因循环菌株的毒力而变化，病毒水平以及其他呼吸道感染的存在。自20世纪20年代鉴定疾病以来，ILT继续影响全球对家禽行业的影响。该疾病主要由生物安全和疫苗接种的组合控制。第一个商业疫苗在20世纪50年代后期和20世纪60年代初推出，是鸡胚源性衰减疫苗。 1970年代后期引入了组织培养物疫苗。重组病毒载体ILT疫苗首先在美国在2000年代中引入，现在它们在全球范围内使用，单独使用或与现场减毒疫苗结合使用。本综述文章提供了我们在世界各地所使用的疫苗和疫苗接种策略中学到的概要，并解决了关于病毒的知识差距和持续未知的宿主交互。

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  • 来源
    《Avian Diseases》 |2019年第2期|共10页
  • 作者

    Garcia Maricarmen; Zavala Guillermo;

  • 作者单位

    Univ Georgia Coll Vet Med Poultry Diagnost &

    Res Ctr Dept Populat Hlth 953 Coll Stn Rd Athens GA 30602 USA;

    Avian Hlth Int LLC 3346 Winder Highway Suite M 135 Flowery Branch GA 30452 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

    ILTV; CEO; TCO; rHVT-LT; rFPV-LT;

    机译：ILTV;首席执行官;TCO;RHVT-LT;RFPV-LT;

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