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首页> 外文期刊>Acta Radiologica >Evaluation of combined Gd-EOB-DTPA and gadobutrol magnetic resonance imaging for the prediction of hepatocellular carcinoma grading
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Evaluation of combined Gd-EOB-DTPA and gadobutrol magnetic resonance imaging for the prediction of hepatocellular carcinoma grading

机译：联合应用Gd-EOB-DTPA和gadobutrol磁共振成像对肝细胞癌分级的预测

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Background Tumor biopsy is not essential for the diagnosis of hepatocellular carcinoma (HCC); however, grading remains important for the prognosis. Purpose To investigate whether combined Gd-EOB-DTPA and gadobutrol liver magnetic resonance imaging (MRI) can predict HCC grading. Material and Methods Thirty patients (66.67.3 years) with histologically confirmed HCC (grade 1, n=5; grade 1-2, n=6; grade 2, n=13; grade 2-3, n=2; grade 3, n=4) underwent two liver MRIs, one with gadobutrol and one with Gd-EOB-DTPA, on consecutive days. Blinded to grading, two radiologists reviewed the gadobutrol and Gd-EOB-DTPA images in consensus with respect to: (i) HCC hyper-/iso-/hypointensity in the arterial, portal-venous/delayed, and Gd-EOB-DTPA hepatocellular phase; and (ii) morphologic tumor features (encapsulated growth, vessel invasion, heterogeneity, liver capsule infiltration, satellite metastases). Results A significant correlation with grading was not found for either the combined dynamic information of all gadobutrol phases (r=-0.187, P=0.331) or all the Gd-EOB-DTPA phases (r=0.052, P=0.802). No correlation with grading was found for a combination of arterial and hepatocellular phase in Gd-EOB-DTPA MRI (r=0.209, P=0.305), a combination of both arterial phases (gadobutrol and Gd-EOB-DTPA) with the Gd-EOB-DTPA hepatocellular phase (r=0.240, P=0.248), or a combination of all available gadobutrol and Gd-EOB-DTPA phases (r=0.086, P=0.691). For all gadobutrol information (dynamic phases and morphology; r=0.049, P=0.801) and for all Gd-EOB-DTPA information (r=0.040, P=0.845), no correlation with grading was found. Hepatocellular Gd-EOB-DTPA phase iso-/hyperintensity never occurred in grade 3 HCCs. Conclusion Histological HCC grading cannot be predicted by combined Gd-EOB-DTPA/gadobutrol MRI. However, Gd-EOB-DTPA hepatocellular phase iso-/hyperintensity was never detected in grade 3 HCCs.
机译：背景肿瘤活检对于肝细胞癌（HCC）的诊断不是必不可少的。但是，分级对预后仍然很重要。目的探讨联合使用Gd-EOB-DTPA和加多布特罗肝磁共振成像（MRI）能否预测HCC分级。材料和方法30例经组织学证实为HCC的患者（66.67.3岁）（1级，n = 5; 1-2级，n = 6; 2级，n = 13; 2-3级，n = 2; 3级） ，n = 4）连续几天进行两次肝脏MRI，其中一次使用gadobutrol，另一次使用Gd-EOB-DTPA。失明至分级，两名放射科医生就以下方面达成共识：对gadobutrol和Gd-EOB-DTPA图像进行了共识：相; （ii）形态学肿瘤特征（包囊生长，血管侵袭，异质性，肝囊浸润，卫星转移）。结果在所有gadobutrol相（r = -0.187，P = 0.331）或所有Gd-EOB-DTPA相（r = 0.052，P = 0.802）的组合动态信息中均未发现与分级显着相关。在Gd-EOB-DTPA MRI中，动脉和肝细胞相的组合（r = 0.209，P = 0.305），两种动脉相（加多布特罗和Gd-EOB-DTPA）与Gd- EOB-DTPA肝细胞期（r = 0.240，P = 0.248），或所有可用的gadobutrol和Gd-EOB-DTPA期的组合（r = 0.086，P = 0.691）。对于所有的gadobutrol信息（动态相和形态; r = 0.049，P = 0.801）和所有Gd-EOB-DTPA信息（r = 0.040，P = 0.845），均未发现与分级相关。在3级HCC中从未发生肝细胞Gd-EOB-DTPA相等强度/高强度。结论联合Gd-EOB-DTPA / gadobutrol MRI无法预测HCC的组织学分级。但是，从未在3级HCC中检测到Gd-EOB-DTPA肝细胞相等-/高强度。

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