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首页> 外文期刊>Annual Review of Phytopathology >Activity and Phylogenetics of the Broadly Occurring Family of Microbial Nep1-Like Proteins
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Activity and Phylogenetics of the Broadly Occurring Family of Microbial Nep1-Like Proteins

机译：广泛发生的微生物Nep1样蛋白的活性和系统发育

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摘要

Necrosis- and ethylene-inducing peptide 1 (Nep1)-like proteins (NLP) have an extremely broad taxonomic distribution; they occur in bacteria, fungi, and oomycetes. NLPs come in two forms, those that are cytotoxic to eudicot plants and those that are noncytotoxic. Cytotoxic NLPs bind to glycosyl inositol phosphoryl ceramide (GIPC) sphingolipids that are abundant in the outer leaflet of plant plasma membranes. Binding allows the NLP to become cytolytic in eudicots but not monocots. The function of noncytotoxic NLPs remains enigmatic, but the expansion of NLP genes in oomycete genomes suggests they are important. Several plant species have evolved the capacity to recognize NLPs as molecular patterns and trigger plant immunity, e.g., Arabidopsis thaliana detects nlp peptides via the receptor-like protein RLP23. In this review, we provide a historical perspective from discovery to understanding of molecular mechanisms and describe the latest developments in the NLP field to shed light on these fascinating microbial proteins.
机译：坏死和乙烯诱导的肽1（NEP1） - 状蛋白（NLP）具有极其广泛的分类分类分析;它们发生在细菌，真菌和oomycetes中。 NLPS有两种形式，那些是犹豫植物的细胞毒性和非胞性毒性的那些形式。细胞毒性NLP与糖基肌醇磷酸酰胺（GIPC）鞘磷脂结合，该鞘磷脂在植物质膜外叶子中丰富。结合允许NLP在拒于但不是单焦点中的细胞分解。非胞菌毒性NLP的功能仍然是神秘的，但在Oomycete基因组中的NLP基因的扩展表明它们是重要的。几种植物物种已经进化了识别NLP的能力，作为分子模式，触发植物免疫，例如拟南芥通过受体样蛋白RLP23检测NLP肽。在这篇综述中，我们提供了从发现到解分子机制的历史视角，并描述了NLP领域的最新动态，在这些迷人的微生物蛋白上脱光。

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