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首页> 外文期刊>Immunobiology: Zeitschrift fur Immunitatsforschung >Tumor infiltrating lymphocytes from acute myeloid leukemia marrow can be reverted to CD45RA+central memory state by reactivation in SIP (Simulated Infective Protocol)
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Tumor infiltrating lymphocytes from acute myeloid leukemia marrow can be reverted to CD45RA+central memory state by reactivation in SIP (Simulated Infective Protocol)

机译：通过再激活（模拟感染方案），可以将来自急性髓性白血病骨髓的肿瘤浸润淋巴细胞从急性髓性白血病骨髓恢复到CD45ra +中央记忆状态（模拟感染方案）

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摘要

Simulated Infective Protocol (SIP) is an ex-vivo culture system modeled after the temporal changes of essential cytokines in an acute infection, and previously proven successful in converting T lymphocytes harvested and activated from peripheral blood of normal donors, to revertant CD45RA + Central Memory T lymphocytes (Tcmra) demonstrating properties akin to T Memory Stem Cells (Tscm). In this study, we applied similar SIP on tumor infiltrating lymphocytes (TIL) from bone marrow of patients diagnosed with acute myeloid leukemia (AML), and replicated the feasibility to convert activated TILs into Tcmra phenotype. These revertant Tcmra lymphocytes re-expressed CD45RA +, CCR7 +, CD62L + and CD127 +, shown improved survivability with longer telomere length, expressed memory properties including higher Eomes to Tbet ratio, and exhibited cytotoxicity against autologous AML blast cells.
机译：模拟感染方案（SIP）是在急性感染中必需细胞因子的时间变化之后建模的前体内培养系统，先前经过成功转换为普通供体的外周血而收获和激活的T淋巴细胞，以回复CD45RA +中央记忆 T淋巴细胞（TCMRA）展示类似于T记忆干细胞（TSCM）的性质。 在这项研究中，我们在诊断患有急性髓白血病（AML）的患者的骨髓中施加类似的SIP患者肿瘤浸润淋巴细胞（直到），并将可行性转化为TCMRA表型转化为TCMRA表型。 这些回复剂TCMRA淋巴细胞重新表达了CD45RA +，CCR7 +，CD62L +和CD127 +，表达了更高的端粒长度，表达的记忆性能，包括更高的沸点与TBET比率，并表现出对自体AML喷射细胞的细胞毒性。

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