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首页> 外文期刊>Immunologic Research: A Selective Reference to Current Research and Practice >Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection
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Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection

机译：神经生长因子（NGF）的中和抑制TH2的反应并保护呼吸道合胞病毒（RSV）感染

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Increasing evidence suggests that respiratory syncytial virus (RSV) infection during the early life is an important risk factor for the development of asthma. RSV infection is associated with neurogenic inflammation in the airways along with the increased expression of nerve growth factor (NGF). However, the role of NGF in RSV infection is not clear. In this study, we infected the rat with RSV and treated these animals with anti-NGF neutralization antibody. We found that anti-NGF treatment significantly alleviated the lung inflammation as evidenced by decreased inflammatory infiltration and decreased airway resistance. Importantly, anti-NGF treatment resulted in increased Th1, but decreased Th2 immune responses, and facilitated the viral control in the tissues and blood. Therefore, NGF inhibited Th2 but increased Th1 responses in RSV infection. Pharmacological intervention of NGF signaling during severe RSV infections could prevent or decrease further asthma symptoms.
机译：越来越多的证据表明，早期生命期间的呼吸道合胞病毒（RSV）感染是哮喘发展的重要危险因素。 RSV感染与气道中的神经源性炎症相关，以及神经生长因子（NGF）的表达增加。 然而，NGF在RSV感染中的作用尚不清楚。 在这项研究中，我们用RSV感染了大鼠并用抗NGF中和抗体治疗这些动物。 我们发现，抗NGF治疗显着减轻了肺炎，通过降低的炎症浸润和减少气道阻力来证明。 重要的是，抗NGF处理导致TH1增加，但减少了Th2免疫应答，并促进了组织和血液中的病毒对照。 因此，NGF抑制TH2，但在RSV感染中增加了TH1反应。 在严重的RSV感染期间NGF信号传导的药理干预可以预防或降低进一步的哮喘症状。

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