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首页> 外文期刊>Immunologic Research: A Selective Reference to Current Research and Practice >Fine-tuning immune surveillance by fever-range thermal stress.
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Fine-tuning immune surveillance by fever-range thermal stress.

机译：发热范围热应力进行微调免疫监测。

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An effectively orchestrated immune response to infection and disease depends on efficient trafficking of lymphocytes across vascular beds at distinct tissue sites. Local inflammation and systemic fever increase immune surveillance to immune-relevant sites throughout the body. During the initiation phase of inflammation, this tightly regulated process improves leukocyte trafficking to the secondary lymphoid organs where they undergo activation and expansion in response to cognate antigen. In the resolution phase following the clearance of the invading pathogen, lymphocyte entry is rapidly returned to baseline conditions. Specialized blood vessels termed high endothelial venules (HEVs) have emerged as critical 'hotspots' controlling the rate of lymphocyte entry into lymphoid organs during both phases of inflammation. In this review, we will examine the remarkably tight regulation of lymphocyte trafficking across HEVs conferred by inflammatory cues associated with the thermal element of fever. These studies have revealed a novel role for interleukin-6 (IL-6) trans-signaling in eliciting systemic effects on lymphocyte trafficking patterns to fine-tune immune surveillance.
机译：有效地协调对感染和疾病的免疫应答取决于在不同组织部位的血管床上有效地贩运淋巴细胞。局部炎症和全身性能会使整个身体的免疫相关部位增加免疫监测。在炎症的起始阶段期间，这种紧张的过程改善了白细胞贩运的二次淋巴结器，在其经历激活和扩张以反应同源抗原。在侵入病原体清除后的分辨率阶段，淋巴细胞进入迅速恢复到基线条件。所谓的专业血管称为高内皮静脉（HEV）作为临界“热点”在炎症的两阶段期间控制淋巴细胞进入淋巴器官的淋巴细胞进入速率。在这篇综述中，我们将研究与热元素的热元素相关的炎症线索赋予HEV显着紧张的淋巴细胞贩运的调节。这些研究揭示了白细胞介素-6（IL-6）反式信令在引发对淋巴细胞贩运模式对微调免疫监测的全身效应方面的一种新颖作用。

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