...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunologic Research: A Selective Reference to Current Research and Practice >The role of the T-cell costimulatory molecule Tim-1 in the immune response.
【24h】

The role of the T-cell costimulatory molecule Tim-1 in the immune response.

机译：T细胞共刺激分子TIM-1在免疫应答中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Upon encountering antigen, CD4+ T-cells become activated and can differentiate into subsets with distinct functional characteristics. One of these subsets is the Th2 cell, which generates large amounts of interleukin (IL)-4, -5, -10 and -13 in response to a subsequent encounter with antigen. In the context of a protective immune response, Th2 cells promote immune cell activation, antibody production, and inflammatory responses that help clear infections. However, aberrant responses by Th2 cells can lead to debilitating allergic diseases such as asthma. Thus, a reasonable approach toward gaining novel insights into immunity and allergic disease is to define the mechanisms that control Th2 cell differentiation and mature Th2 cell function. Recent work suggests that a protein called Tim-1 (T-cell immunoglobulin and mucin protein-1) is expressed on CD4+ T-cells and plays a central role in regulating Th2 responses. Genetic analysis has linked polymorphisms in the human TIM1 gene to susceptibility to allergic disease, while studies involving mice have shown that ligation of Tim-1 promotes CD4+ T-cell activation. The signal transduction pathways downstream of Tim-1 are a relatively unexplored area. Continued study will undoubtedly reveal novel insights regarding the relationships between Tim-1, Th2 responses, and allergic disease.
机译：在遇到抗原后，CD4 + T细胞被激活，并且可以分化为具有不同功能特性的子集。这些子集中的一种是TH2细胞，其响应于随后与抗原的遭遇产生大量的白细胞介素（IL）-4，-5，-10和-13。在保护性免疫应答的背景下，Th2细胞促进免疫细胞活化，抗体产生和有助于清除感染的炎症反应。然而，TH2细胞的异常反应可以导致衰弱的过敏性疾病，例如哮喘。因此，朝着抗免疫和过敏性疾病获得新颖洞察的合理方法是定义控制Th2细胞分化和成熟Th2细胞功能的机制。最近的工作表明，称为TIM-1（T细胞免疫球蛋白和粘蛋白-1）的蛋白质在CD4 + T细胞上表达，并在调节TH2响应方面发挥着中心作用。遗传分析在人TIM1基因中将多态性与过敏性疾病的易感性有易感性，而涉及小鼠的研究表明，TIM-1的连接促进了CD4 + T细胞活化。 Tim-1下游的信号转导通路是相对未开发的区域。持续的研究无疑将揭示关于TIM-1，TH2反应和过敏疾病之间的关系的新颖见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号