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首页> 外文期刊>Acta Radiologica >Measurement of coronary flow response to cold pressor stress in asymptomatic women with cardiovascular risk factors using spiral velocity-encoded cine MRI at 3 Tesla.
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Measurement of coronary flow response to cold pressor stress in asymptomatic women with cardiovascular risk factors using spiral velocity-encoded cine MRI at 3 Tesla.

机译：在3特斯拉使用螺旋速度编码的电影MRI测量无症状女性中有心血管危险因素的冠状动脉血流对冷压应激的反应。

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Background: Coronary sinus (CS) flow in response to a provocative stress has been used as a surrogate measure of coronary flow reserve, and velocity-encoded cine (VEC) magnetic resonance imaging (MRI) is an established technique for measuring CS flow. In this study, the cold pressor test (CPT) was used to measure CS flow response because it elicits an endothelium-dependent coronary vasodilation that may afford greater sensitivity for detecting early changes in coronary endothelial function. Purpose: To investigate the feasibility and reproducibility of CS flow reactivity (CSFR) to CPT using spiral VEC MRI at 3 Tesla in a sample of asymptomatic women with cardiovascular risk factors. Material and Methods: Fourteen asymptomatic women (age 38 years +/- 10) with cardiovascular risk factors were studied using 3D spiral VEC MRI of the CS at 3 T. The CPT was utilized as a provocative stress to measure changes in CS flow. CSFR to CPT was calculated from the ratio of CS flow during peak stress to baseline CS flow. Results: CPT induced a significant hemodynamic response as measured by a 45% increase in rate-pressure product (P<0.01). A significant increase in CS volume flow was also observed (baseline, 116 +/- 26 ml/min; peak stress, 152 +/- 34 ml/min, P=0.01). CSFR to CPT was 1.31 +/- 0.20. Test-retest variability of CS volume flow was 5% at baseline and 6% during peak stress. Conclusion: Spiral CS VEC MRI at 3 T is a feasible and reproducible technique for measuring CS flow in asymptomatic women at risk for cardiovascular disease. Significant changes in CSFR to CPT are detectable, without demanding pharmacologic stress.
机译：背景：响应刺激性应激的冠状窦（CS）流量已被用作冠状动脉血流储备的替代量度，而速度编码电影（VEC）磁共振成像（MRI）是一种用于测量CS流量的成熟技术。在这项研究中，使用冷压试验（CPT）来测量CS血流反应，因为它引起了内皮依赖性冠状动脉舒张血管扩张，可为检测冠状动脉内皮功能的早期变化提供更高的敏感性。目的：在3特斯拉使用螺旋VEC MRI研究无心血管疾病危险因素的女性样本中，研究CS流动反应（CSFR）对CPT的可行性和可重复性。材料和方法：使用3D CS在3 T时进行的3D螺旋VEC MRI研究了14名无症状女性（年龄38岁+/- 10），具有心血管危险因素。CPT被用作挑衅性压力来测量CS流量的变化。 CSFR至CPT由峰值应力期间CS流量与基线CS流量之比计算得出。结果：CPT引起显着的血液动力学反应，通过速率压力乘积增加45％来测量（P <0.01）。还观察到CS体积流量显着增加（基线：116 +/- 26 ml / min;峰值应力：152 +/- 34 ml / min，P = 0.01）。 CPT的CSFR为1.31 +/- 0.20。 CS体积流量的重测变异性在基线时为5％，在峰值应力时为6％。结论：3 T螺旋CS VEC MRI是一种可行且可重复的技术，可用于测量有心血管疾病风险的无症状女性的CS流量。 CSFR到CPT的显着变化是可检测的，而无需药理学压力。

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