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首页> 外文期刊>Acta Radiologica >MRI of the cat brain in the study of vascular permeability after intraarterial carotid injection of triolein.
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MRI of the cat brain in the study of vascular permeability after intraarterial carotid injection of triolein.

机译：MRI对猫脑进行颈动脉内注射三油精后血管通透性的研究。

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BACKGROUND: Triolein emulsion embolization into the carotid artery depicts reversible increased vascular permeability that can promote the effect of chemotherapy or can reduce the amount of chemotherapeutic drugs for equivalent effectiveness. PURPOSE: To establish the minimum dosage of 0.5% triolein for studying vascular permeability changes in a triolein emulsion model. MATERIAL AND METHODS: Sixty-six cats were divided into six groups based on the amount of emulsified triolein (0.5%) infused into the carotid artery: group 1 (n=12, 6 ml/kg), group 2 (n=12, 4.5 ml/kg), group 3 (n=12, 3 ml/kg), group 4 (n=10, 1.5 ml/kg), group 5 (n=10, 1 ml/kg), and group 6 (n=10, 3 ml/kg of saline (control group)). T1-weighted, T2-weighted, and post-contrast T1-weighted MRI was performed 2 h after the infusion of the triolein emulsion. Contrast enhancement ratios (CERs) were obtained with pre- and post-contrast T1-weighted images in the ipsilateral and contralateral hemispheres. Signal intensity ratios (SIRs) of the ipsilateral and contralateral hemispheres were evaluated on T2-weighted images. After removal of the brain tissues, edema ratios in the ipsilateral and contralateral hemispheres were obtained from wet versus dry brain weights. Data were statistically evaluated by analysis of variance, followed by the Tukey honestly significant difference test to compare the difference in the mean CER of the ipsilateral and contralateral hemispheres, mean SIR on T2-weighted image, and mean edema ratio between each group when overall significance was attained. RESULTS: In the ipsilateral hemispheres, the difference in the CER between the control group and groups 1 (P=0.004), 2 (P=0.043), and 3 (P=0.008) were statistically significant. The difference in the CERs between the triolein emulsion groups was not statistically significant (P>0.05). The T2-weighted SIRs were significantly different between the control group and groups 1 (P=0.027) and 2 (P=0.004). However, the edema ratios of all doses in the triolein emulsion groups showed no significant differences compared with the control group. CONCLUSION: The minimum dosage of 0.5% triolein emulsion to achieve increased vascular permeability in the hemisphere in cat brains appears to be 3 ml/kg. This minimum dosage of triolein emulsion can be useful for acquiring basic data in further studies of vascular permeability changes in a triolein emulsion model.
机译：背景：三油精乳剂栓塞入颈动脉显示出可逆性增加的血管通透性，可以促进化学疗法的效果或可以减少化学治疗药物的量，以达到等效效果。目的：建立最小剂量的0.5％三油精，以研究三油精乳剂模型中的血管通透性变化。材料与方法：根据注入颈动脉的乳化油精（0.5％）的量，将66只猫分为六组：第一组（n = 12，6 ml / kg），第二组（n = 12， 4.5 ml / kg），第3组（n = 12、3 ml / kg），第4组（n = 10、1.5 ml / kg），第5组（n = 10、1 ml / kg）和第6组（n = 10，3 ml / kg盐水（对照组）。输注三油精乳剂后2小时，进行T1加权，T2加权和对比后T1加权MRI。在同侧和对侧半球中，使用对比前后的T1加权图像获得对比增强率（CER）。在T2加权图像上评估同侧和对侧半球的信号强度比（SIR）。去除脑组织后，从干重与干重获得同侧和对侧半球的水肿率。通过方差分析对数据进行统计学评估，然后进行Tukey诚实显着差异检验，以比较同侧和对侧半球的平均CER，T2加权图像上的平均SIR和每组之间的总体水肿率（当具有总体意义时）达到了。结果：在同侧半球中，对照组和第1组（P = 0.004），第2组（P = 0.043）和第3组（P = 0.008）之间的CER差异具有统计学意义。三油精乳剂组之间的CER差异无统计学意义（P> 0.05）。对照组与第1组（P = 0.027）和第2组（P = 0.004）之间的T2加权SIR显着不同。但是，三油精乳剂组中所有剂量的水肿率与对照组相比没有显着差异。结论：为增加猫脑半球血管通透性的0.5％三油精乳剂的最小剂量为3 ml / kg。三油精乳剂的这一最小剂量可用于获取基础数据，以进一步研究三油精乳剂模型中的血管通透性变化。

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