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首页> 外文期刊>Annual Review of Immunology >New Molecular Insights into Immune Cell Development
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New Molecular Insights into Immune Cell Development

机译：新分子见解免疫细胞发育

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During development innate lymphoid cells and specialized lymphocyte subsets colonize peripheral tissues, where they contribute to organogenesis and later constitute the first line of protection while maintaining tissue homeostasis. A few of these subsets are produced only during embryonic development and remain in the tissues throughout life. They are generated through a unique developmental program initiated in lympho-myeloid-primed progenitors, which lose myeloid and B cell potential. They either differentiate into innate lymphoid cells or migrate to the thymus to give rise to embryonic T cell receptor-invariant T cells. At later developmental stages, adaptive T lymphocytes are derived from lympho-myeloid progenitors that colonize the thymus, while lymphoid progenitors become specialized in the production of B cells. This sequence of events highlights the requirement for stratification in the establishment of immune functions that determine efficient seeding of peripheral tissues by a limited number of cells.
机译：在开发先天淋巴细胞和专门的淋巴细胞亚群中殖民化外周组织，它们有助于组织发生，后来构成第一线保护线，同时保持组织稳态。这些子集中的一些仅在胚胎发育期间产生并在整个生命中留在组织中。它们是通过在淋巴 - 髓样灌注血管血管血管血管血浆剂中引发的独特发育计划而产生的，这失去了髓样和B细胞潜力。它们要么分化为先天淋巴细胞，或迁移到胸腺，以产生胚胎T细胞受体 - 不变的T细胞。在后期的发育阶段，适应性T淋巴细胞源自淋巴 - 髓样祖细胞，其殖民化胸腺，而淋巴祖细胞均为B细胞的生产。这种事件序列突出了在建立免疫功能中的分层的要求，该免疫功能通过有限数量的细胞确定外周组织的有效接种。

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