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Double-Stranded RNA Sensors and Modulators in Innate Immunity

机译:双链RNA传感器和调节剂在先天免疫力

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摘要

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity. This review aims to highlight their interconnectivity, as well as their commonalities and differences in their dsRNA recognition mechanisms.
机译:检测双链RNA(DSRNA)是许多生物体中先天免疫防御的中央机制。 我们在这里讨论了涉及哺乳动物抗病毒先天免疫的几个Dsrna结合蛋白质。 这些包括钻石-i样受体,蛋白激酶R,脱烯基酯合成酶,作用于RNA,RNA干扰系统和含有dsRNA结合结构域和螺旋酶结构域的其他蛋白质的腺苷脱烯酸酯。 研究表明,他们的功能是非常相互依存的,它们的相互依赖性可以提供理解细胞DSRNA稳态和抗病毒免疫力的复杂调节机制的关键。 该审查旨在突出互联性,以及他们的互联网识别机制的共同性和差异。

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