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首页> 外文期刊>Annual Review of Immunology >Disease Tolerance as an Inherent Component of Immunity
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Disease Tolerance as an Inherent Component of Immunity

机译：疾病耐受作为免疫力的固有成分

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摘要

Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs of infectious diseases. Immunity limits the severity of infectious diseases through resistance mechanisms that sense and target pathogens for containment, killing, or expulsion. These resistance mechanisms are viewed as the prevailing function of immunity. Under pathophysiologic conditions, however, immunity arises in response to infections that carry health and fitness costs to the host. Therefore, additional defense mechanisms are required to limit these costs, before immunity becomes operational as well as thereafter to avoid immunopathology. These are tissue damage control mechanisms that adjust the metabolic output of host tissues to different forms of stress and damage associated with infection. Disease tolerance is the term used to define this defense strategy, which does not exert a direct impact on pathogens but is essential to limit the health and fitness costs of infection. Under this argument, we propose that disease tolerance is an inherent component of immunity.
机译：病原生物对宿主健康产生负面影响，通过传染病的临床症状揭示。免疫通过抵抗机制来限制传染性疾病的严重程度，感知和靶病原体用于遏制，杀害或排出。这些电阻机制被视为免疫力的主要功能。然而，在病理生理学条件下，抗扰度是响应患者对主持人的健康和健身成本的感染而产生的。因此，在免疫变得操作之前，需要额外的防御机制来限制这些成本，以及此后避免免疫病理学。这些是组织损伤控制机制，可将宿主组织的代谢输出调整到不同形式的应力和与感染相关的损伤。疾病耐受是用于定义这种防御策略的术语，这对病原体并不产生直接影响，但对于限制感染的健康和健身成本至关重要。在此论点下，我们提出疾病耐受性是免疫的固有成分。

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