• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual Review of Immunology >Nonclassical Monocytes in Health and Disease
【24h】

Nonclassical Monocytes in Health and Disease

机译：健康和疾病中的非生物单核细胞

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monocytes are innate blood cells that maintain vascular homeostasis and are early responders to pathogens in acute infections. There are three well-characterized classes of monocytes: classical (CD14(+)CD16(-) in humans and Ly6C(hi) in mice), intermediate (CD14(+)CD16(+) in humans and Ly6C(+)Treml4(+) in mice), and nonclassical (CD14(-)CD16(+) in humans and Ly6C(lo) in mice). Classical monocytes are critical for the initial inflammatory response. Classical monocytes can differentiate into macrophages in tissue and can contribute to chronic disease. Nonclassical monocytes have been widely viewed as anti-inflammatory, as they maintain vascular homeostasis. They are a first line of defense in recognition and clearance of pathogens. However, their roles in chronic disease are less clear. They have been shown to be protective as well as positively associated with disease burden. This review focuses on the state of the monocyte biology field and the functions of monocytes, particularly nonclassical monocytes, in health and disease.
机译：单核细胞是血管血细胞的先天血细胞，并且是急性感染病原体的早期响应者。有三种特征在于一组单核细胞类别：古典（CD14（+）CD16（ - ）在人和Ly6C（HI）中，人和Ly6C（+）Treml4中中间体（CD14（+）CD16（+）（ +）在小鼠中，和在小鼠中的人和Ly6c（LO）中的非类（CD14（ - ）CD16（+））。经典单核细胞对于初始炎症反应至关重要。经典单核细胞可以分化为组织中的巨噬细胞，可以有助于慢性疾病。非生物质单核细胞已被广泛观察为抗炎，因为它们保持血管稳态。它们是识别和清除病原体的第一道防线。然而，它们在慢性疾病中的作用不太清楚。它们被证明是保护性的，以及与疾病负担有关的保护性。本综述重点介绍了单核细胞生物领域的状态和单核细胞，特别是非核心单核细胞的功能，健康和疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号