Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

Lindenbergh Marthe F. S.; Stoorvogel Willem

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Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

机译：来自专业抗原呈递细胞的细胞外囊的抗原呈现

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The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted by multivesicular endosomes. Membrane receptors guide EVs to specific target cells, allowing directional transfer of specific and complex signaling cues. EVs are released by most, if not all, immune cells. Depending on the type and status of their originating cell, EVs may facilitate the initiation, expansion, maintenance, or silencing of adaptive immune responses. This review focusses on EVs from professional antigen-presenting cells, their demonstrated and speculated roles, and their potential for cancer immunotherapy.

机译：自适应免疫的起始和维持需要不同类型的免疫细胞之间的多方沟通方式，包括直肠间触点，分泌的可溶信号传导分子和细胞外囊泡（EVS）。 EVS可以形成为从血浆膜直接挤出的微泡，或者通过多友多骨囊分泌的外泌体。膜受体引导EVS至特定的靶细胞，允许特定和复杂的信号线的定向转移。 EVS由大多数，如果不是全部，免疫细胞释放。根据其始发细胞的类型和状态，EVS可以促进适应性免疫反应的启动，扩展，维护或沉默。本综述侧重于专业抗原呈递细胞的EVS，其证明和推测的角色以及它们对癌症免疫疗法的潜力。

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来源
《Annual Review of Immunology》 |2018年第2018期|共25页
作者
Lindenbergh Marthe F. S.; Stoorvogel Willem;
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作者单位

Univ Utrecht Fac Vet Med Dept Biochem &

Cell Biol NL-3508 TD Utrecht Netherlands;

Univ Utrecht Fac Vet Med Dept Biochem &

Cell Biol NL-3508 TD Utrecht Netherlands;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
exosomes; microvesicles; MHC molecules; dendritic cells; B cells; T cells;

机译：外来;微胶囊;MHC分子;树突细胞;B细胞;T细胞;

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专利

1. Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells [J] . Lindenbergh Marthe F. S., Stoorvogel Willem Annual Review of Immunology . 2018,第期

机译：来自专业抗原呈递细胞的细胞外囊的抗原呈现
2. Presentation of Toxoplasma gondii Antigens via the Endogenous Major Histocompatibility Complex Class I Pathway in Nonprofessional and Professional Antigen-Presenting Cells [J] . Florence Dzierszinski, Marion Pepper, Jason S. Stumhofer, Infection and immunity . 2007,第11期

机译：通过非专业和专业抗原呈递细胞中的内源性主要组织相容性复合体I类途径呈递弓形虫抗原。
3. Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses. [J] . Plebanski M, Hannan CM, Behboudi S, Immunology and Cell Biology . 2005,第3期

机译：专业抗原呈递细胞在诱导CD8 T细胞反应中直接加工和呈递来自疟疾子孢子的抗原。
4. Investigating the interaction forces between T cells and antigen-presenting cells using an optical trapping system [C] . Amanda J. Wright, Robert A. Benson, Richard W. Bowman, Optical trapping and optical micromanipulation VIII . 2011

机译：使用光学捕获系统研究T细胞与抗原呈递细胞之间的相互作用力
5. An Investigation of Microfluidic Produced Hydrogel Vesicles for Artificial Antigen-Presenting Cell Applications [D] . Chen, Lindsay. 2021

机译：用于人工抗原呈递细胞应用的微流体生产水凝胶囊泡的研究
6. Presentation of Toxoplasma gondii Antigens via the Endogenous Major Histocompatibility Complex Class I Pathway in Nonprofessional and Professional Antigen-Presenting Cells [O] . Florence Dzierszinski, Marion Pepper, Jason S. Stumhofer, 2007

机译：通过非专业和专业抗原呈递细胞中的内源性主要组织相容性复合体I类途径呈递弓形虫抗原。
7. Presentation of Toxoplasma gondii Antigens via the Endogenous Major Histocompatibility Complex Class I Pathway in Nonprofessional and Professional Antigen-Presenting Cells▿ [O] . Dzierszinski, Florence, Pepper, Marion, Stumhofer, Jason S., 2007

机译：在非专业和专业抗原呈递细胞中通过内源性主要组织相容性复合体I类途径呈递弓形虫抗原▿

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

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