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首页> 外文期刊>Annual Review of Immunology >Regulation of the Cell Biology of Antigen Cross-Presentation
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Regulation of the Cell Biology of Antigen Cross-Presentation

机译：调节抗原交叉呈递的细胞生物学

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摘要

Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells. The physical separation of internalized cargo from the endoplasmic reticulum, where the machinery for assembling peptide-MHC-I complexes resides, poses a challenge. To solve this problem, deliberate rewiring of organelle communication within cells is necessary to prepare for cross-presentation, and different endocytic receptors and vesicular traffic patterns customize the emergent cross-presentation compartment to the nature of the peptide source. Three distinct pathways of vesicular traffic converge to form the ideal cross-presentation compartment, each regulated differently to supply a unique component that enables cross-presentation of a diverse repertoire of peptides. Delivery of centerpiece MHC-I molecules is the critical step regulated by microbe-sensitive Toll-like receptors. Defining the subcellular sources of MHC-I and identifying sites of peptide loading during cross-presentation remain key challenges.
机译：抗原交叉呈现是在其在其生物合成中加载MHC-I分子的细胞过程，在其生物合成中加载MHC-1分子在内质网内的生物合成中。交叉呈递的肽来自内化蛋白质，微生物病原体和转化或染色细胞。内化货物从内质网的物理分离，其中用于组装肽-MHC-I复合物的机械呈现，构成挑战。为了解决这个问题，需要在细胞内进行细胞器通信的重新灌注是必要的，以准备交叉呈递，并且不同的内吞受体和囊状交通模式定制出肽源的性质的紧急交叉呈现室。三个不同的囊泡交通途径融合以形成理想的交叉呈现隔间，每个横向呈现隔间，各种各样的调节方式，以提供一种独特的组件，使能够交叉呈现肽的各种曲目。核心MHC-I分子的递送是通过微生物敏感的沟壑的受体调节的关键步骤。定义MHC-I的亚细胞来源和横向呈现期间肽负载的鉴定部位仍然是关键挑战。

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