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首页> 外文期刊>Annual Review of Immunology >Signaling and Function of Interleukin-2 in T Lymphocytes
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Signaling and Function of Interleukin-2 in T Lymphocytes

机译：白细胞介素-2在T淋巴细胞中的信号和功能

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The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro-and anti-inflammatory T cells is fundamental to determining the molecular details of immune regulation. The IL-2 receptor couples to JAK tyrosine kinases and activates the STAT5 transcription factors. However, IL-2 does much more than control transcriptional programs; it is a key regulator of T cell metabolic programs. The development of global phosphoproteomic approaches has expanded the understanding of IL-2 signaling further, revealing the diversity of phosphoproteins that may be influenced by IL-2 in T cells. However, it is increasingly clear that within each T cell subset, IL-2 will signal within a framework of other signal transduction networks that together will shape the transcriptional and metabolic programs that determine T cell fate.
机译：白细胞介素-2（IL-2）的发现改变了对免疫系统如何控制的分子理解。 IL-2是一种磷酸细胞因子，并将允许IL-2的信号传导途径解剖，以控制亲和抗炎T细胞的分化和稳态是确定免疫调节的分子细节的基础。 IL-2受体对Jak Tyrosine激酶致其激活STAT5转录因子。但是，IL-2的不仅仅是控制转录计划;它是T细胞代谢程序的关键调节因子。全局磷蛋白酶方法的发展进一步扩展了对IL-2信号传导的理解，揭示了在T细胞中可能受IL-2影响的磷蛋白的多样性。然而，越来越清楚的是，在每个T小区子集内，IL-2将在其他信号转换网络的框架内发信号，该网络将塑造确定T细胞命运的转录和代谢程序。

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