RIG-I and Other RNA Sensors in Antiviral Immunity

Chow Kwan T.; Gale Michael Jr.; Loo Yueh-Ming

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RIG-I and Other RNA Sensors in Antiviral Immunity

机译：抗病毒免疫中的RIG-I和其他RNA传感器

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Pattern recognition receptors (PRRs) survey intra- and extracellular spaces for pathogen-associated molecular patterns (PAMPs) within microbial products of infection. Recognition and binding to cognate PAMP ligand by specific PRRs initiates signaling cascades that culminate in a coordinated intracellular innate immune response designed to control infection. In particular, our immune system has evolved specialized PRRs to discriminate viral nucleic acid from host. These are critical sensors of viral RNA to trigger innate immunity in the vertebrate host. Different families of PRRs of virus infection have been defined and reveal a diversity of PAMP specificity for wide viral pathogen coverage to recognize and extinguish virus infection. In this review, we discuss recent insights in pathogen recognition by the RIG-I-like receptors, related RNA helicases, Toll-like receptors, and other RNA sensor PRRs, to present emerging themes in innate immune signaling during virus infection.

机译：图案识别受体（PRRS）对感染微生物产品中的病原体相关分子模式（PAMPS）的病理和细胞外空间进行调查。特异性PRRS识别和结合对同源PAMP配体的鉴别和结合引发了信号传导级联，所述信号级联在旨在控制感染的协调的细胞内先天免疫应答中达到峰值。特别是，我们的免疫系统已经进化了专门的PRR来鉴别来自宿主的病毒核酸。这些是病毒RNA的关键传感器，以引发脊椎动物宿主中的先天免疫。已经定义了不同病毒感染的不同族，并揭示了宽的病毒病原体覆盖物的粘合性特异性，以识别和灭绝病毒感染。在该综述中，我们讨论了钻机I形受体，相关RNA螺旋酶，收费等RNA传感器PRRS的病原体识别的最近见解，以在病毒感染期间在先天免疫信号传导中呈现出新的主题。

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来源
《Annual Review of Immunology》 |2018年第2018期|共28页
作者
Chow Kwan T.; Gale Michael Jr.; Loo Yueh-Ming;
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作者单位

Univ Washington Ctr Innate Immun &

Immune Dis Seattle WA 98109 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
RIG-I-like receptors; RLR; DExD/H box helicases; Toll-like receptors; TLR; RNA sensing; antiviral immunity; innate immune signaling;

机译：钻石I形受体;RLR;DEXD / H箱螺旋酶;令人伤害的受体;TLR;RNA感测;抗病毒免疫;天生的免疫信号;

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专利

1. RIG-I and Other RNA Sensors in Antiviral Immunity [J] . Chow Kwan T., Gale Michael Jr., Loo Yueh-Ming Annual Review of Immunology . 2018,第期

机译：抗病毒免疫中的RIG-I和其他RNA传感器
2. Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response [J] . JiangX., KinchL.N., BrautigamC.A., Immunity . 2012,第6期

机译：泛素诱导的RNA传感器RIG-I和MDA5的寡聚激活抗病毒的天然免疫反应。
3. RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity. [J] . Yoneyama M, Fujita T Cytokine & growth factor reviews . 2007,第5a6期

机译：RIG-I系列RNA解旋酶：细胞质传感器，用于抗病毒先天免疫。
4. Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I [C] . H. Kato, T. Kawai, S. Uematsu, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：病毒识别和I型干扰素通过Toll样受体和RNA Helicate，RIG-I
5. Mechanistic Studies of RNA Detection by the Cellular Immune Sensors LGP2 and MDA5 in Mammalian Antiviral Signaling. [D] . Bruns, Annie M. 2014

机译：在哺乳动物抗病毒信号中通过细胞免疫传感器LGP2和MDA5检测RNA的机理研究。
6. Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response [O] . Xiaomo Jiang, Lisa Kinch, Chad A. Brautigam, -1

机译：该RNa传感器RIG-I的泛素诱导齐聚和mDa5激活抗病毒先天免疫反应
7. Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response [O] . Jiang Xiaomo, Kinch Lisa N., Brautigam Chad A., 2012

机译：泛素诱导的RNA传感器RIG-I和MDA5的寡聚激活抗病毒先天免疫反应。

RIG-I and Other RNA Sensors in Antiviral Immunity

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