Signaling by Antibodies: Recent Progress

Stylianos Bournazos; Taia T. Wang; Rony Dahan; Jad Maamary; Jeffrey V. Ravetch

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Signaling by Antibodies: Recent Progress

机译：抗体信号传导：最近的进展

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IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoim-munity and responsiveness to antibody-based therapeutics and vaccines.

机译：IgG抗体通过Fab结构域通过Fab结构域偶联抗原特异性以通过Fc-Fc受体相互作用来信号转导的分集体。实际上，通过I型和II型Fc受体的平衡IgG信号传导是控制促炎，抗炎和免疫调节过程所必需的。在本文中，我们讨论了控制IgG-Fc受体相互作用的机制，突出了调节免疫和炎症的Fc受体介导的效应功能的多样性，以及确定对感染和自身密度的敏感性和对基于抗体的治疗的反应性的易感性疫苗。

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来源
《Annual Review of Immunology》 |2017年第2017期|共27页
作者
Stylianos Bournazos; Taia T. Wang; Rony Dahan; Jad Maamary; Jeffrey V. Ravetch;
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作者单位

Laboratory of Molecular Genetics and Immunology The Rockefeller University;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
IgG; Fc receptors; effector function; immunomodulation; immunity; inflammation;

机译：IgG;Fc受体;效应功能;免疫调节;免疫;炎症;

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1. Signaling by Antibodies: Recent Progress [J] . Stylianos Bournazos, Taia T. Wang, Rony Dahan, Annual Review of Immunology . 2017,第期

机译：抗体信号传导：最近的进展
2. Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking [J] . Romain Lanotte, Véronique Garambois, Nadège Gaborit, Cancer science. . 2020,第7期

机译：偏置人表皮生长因子受体4（HER4）抗体酪氨酸激酶信号传导：通过抗体依赖性HER4细胞内域贩运诱导细胞死亡
3. Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling [J] . Annika De Sousa Linhares, Claire Battin, Sabrina Jutz, Scientific reports. . 2019,第1期

机译：治疗性PD-L1抗体比在阻塞PD-1 / PD-L1信号传导中比PD-1抗体更有效
4. Work in progress: Development of an ELISA for the detection of FMDV 3ABC antibody in swine oral fluid specimens [C] . Annual Meeting of the American Association of Swine Veterinarians . 2018

机译：正在进行中的工作：在猪口腔流体样本中检测FMDV 3ABC抗体的ELISA的开发
5. Regulation of Antibody Responses against West Nile virus by the Innate Signaling Adaptor MAVS [D] . O'Ketch, Marvin. 2019

机译：通过先天信号转接头MAVS调节针对西尼罗河病毒的抗体应答
6. Signaling by Antibodies: Recent Progress [O] . Stylianos Bournazos, Taia T. Wang, Rony Dahan, -1

机译：抗体信号传导：最新进展
7. Signaling by Antibodies: Recent Progress [O] . Stylianos Bournazos, Taia T. Wang, Rony Dahan, 2017

机译：抗体信号传导：最近的进展

Signaling by Antibodies: Recent Progress

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