• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual Review of Immunology >Protective and Harmful Immunity to RSV Infection
【24h】

Protective and Harmful Immunity to RSV Infection

机译：对RSV感染的保护和有害免疫力

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects. In addition, RSVs importance as a largely unrecognized pathogen of debilitated older people is increasingly evident. Vaccines that induce nonpathogenic protective immunity may soon be available, and it is possible that different vaccines will be optimal for infants; older children; young to middle-age adults (including pregnant women); and elderly persons. At the dawn of RSV vaccination, it is timely to review what is known (and unknown) about immune responses to this fascinating virus.
机译：呼吸合胞病毒（RSV）是一种特殊的粘膜病原体。它专注于感染纤毛性呼吸上皮，导致可变严重程度的疾病，几乎没有直接的全身效应。几乎所有孩子都在三年内感染，然后在整个生命中反复感染;尽管抗原性相对较差，但显然是通过诱导选择性免疫遗忘的抗原性相对较小。对RSV的不恰当或失调的反应可以是致病性的，导致疾病增强的炎症，这有助于短期和长期效应。此外，RSV非常重要的是衰弱的老年人的一个主要未被忽视的病原体越来越明显。疫苗可以很快获得诱导非对抗保护性免疫的疫苗，并且可能对婴儿的不同疫苗可能是最佳的;年龄较大的孩子;年轻人到中年成年人（包括孕妇）;和老人。在RSV疫苗接种的曙光中，及时审查对这种迷人病毒的免疫反应是已知的（和未知）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号