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首页> 外文期刊>Annual Review of Immunology >The Innate Biologies of Adaptive Antigen Receptors
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The Innate Biologies of Adaptive Antigen Receptors

机译：适应性抗原受体的先天生物学

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Nonclonal innate immune responses mediated by germ line-encoded receptors, such as Toll-like receptors or natural killer receptors, are commonly contrasted with diverse, clonotypic adaptive responses of lymphocyte antigen receptors generated by somatic recombination. However, the Variable (V) regions of antigen receptors include germ line-encoded motifs unaltered by somatic recombination, and theoretically available to mediate nonclonal, innate responses, that are independent of or largely override clonotypic responses. Recent evidence demonstrates that such responses exist, underpinning the associations of particular gamma delta T cell receptors (TCRs) with specific anatomical sites. Thus, TCR gamma delta can make innate and adaptive responses with distinct functional outcomes. Given that alpha beta T cells and B cells can also make nonclonal responses, we consider that innate responses of antigen receptor V-regions may be more widespread, for example, inducing states of preparedness from which adaptive clones are better selected. We likewise consider that potent, nonclonal T cell responses tomicrobial superantigens may reflect subversion of physiologic innate responses of TCR alpha/beta chains.
机译：由胚芽编码的受体（例如Toll样受体或天然杀伤受体）介导的非新生先天免疫应答，通常与体细胞重组产生的淋巴细胞抗原受体的不同锁定适应性反应形成对比。然而，抗原受体的变量（v）区域包括通过体细胞重组未置换的细菌编码的基序，并且理论上可用于介导非全克隆的先天反应，其独立于或大部分覆盖间型反应。最近的证据表明存在这种反应，支撑特定γδTT细胞受体（TCR）与特异性解剖位点的关联。因此，TCRγδ可以用不同的功能结果制作天生和自适应响应。鉴于αβT细胞和B细胞也可以进行非核心反应，我们认为抗原受体V区的先天反应可能更广泛，例如，诱导选择自适应克隆的准备状态。我们同样考虑强大的，非全国性的T细胞反应Tomicrobial Superigens可能反映TCRα/β链的生理原用反应的颠覆。

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