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首页> 外文期刊>Acta Psychiatrica Scandinavica >The contribution of active medication to combined treatments of psychotherapy and pharmacotherapy for adult depression: a meta-analysis.
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The contribution of active medication to combined treatments of psychotherapy and pharmacotherapy for adult depression: a meta-analysis.

机译：活性药物对成人抑郁症心理治疗和药物治疗的联合治疗的贡献：一项荟萃分析。

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OBJECTIVE: Although there is sufficient evidence that combined treatments of psychotherapy and pharmacotherapy are more effective for depression in adults than each of the treatments alone, it remains unclear what the exact contribution of active medication is to the overall effects of combined treatments. This paper examines the contribution of active medication to combined psychotherapy and pharmacotherapy treatments. METHOD: Meta-analysis of randomised controlled trials comparing the combination of psychotherapy and pharmacotherapy with the combination of psychotherapy and placebo. RESULTS: Sixteen identified studies involving 852 patients met our inclusion criteria. The standardised mean difference indicating the differences between the combination of psychotherapy and pharmacotherapy and the combination of psychotherapy and placebo was 0.25 (95% CI: 0.03-0.46), which corresponds to a numbers-needed-to-be-treated of 7.14. No significant differences between subgroups of studies were found. CONCLUSION: Active medication has a small but significant contribution to the overall efficacy of combined treatments.
机译：目的：尽管有充分的证据表明，心理治疗和药物治疗的联合治疗比单独使用每种治疗对成年人的抑郁症更为有效，但仍不清楚活性药物对联合治疗的总体效果有何确切贡献。本文研究了主动药物对心理治疗和药物治疗相结合的贡献。方法：荟萃分析比较心理疗法和药物疗法与心理疗法和安慰剂疗法的随机对照试验。结果：16项确定的研究涉及852名患者，符合我们的纳入标准。表示心理治疗和药物治疗的组合与心理治疗和安慰剂的组合之间的差异的标准平均差为0.25（95％CI：0.03-0.46），对应于需要治疗的数字7.14。研究亚组之间没有发现显着差异。结论：主动用药对联合治疗的整体疗效有很小但重要的贡献。

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