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首页> 外文期刊>Indian Journal of Agricultural Biochemistry >Determination of in-vitro Antioxidant Potential of Bael (Aegle marmelos) Leaf Extract under Sodium Nitrite Induced Oxidative Stress
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Determination of in-vitro Antioxidant Potential of Bael (Aegle marmelos) Leaf Extract under Sodium Nitrite Induced Oxidative Stress

机译：亚硝酸钠诱导氧化胁迫下百尔（Aegle Marmelos）叶提取物体外抗氧化潜力的测定

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摘要

The present study was designed to determine the antioxidant potential of aqueous extract of Bael leaves (Aegle marmelos) using sodium nitrite stressed PC-12 cells. The aqueous extract of dried Bael leaf showed increased levels of antioxidant enzymes including superoxide dismutase (SOD) and catalase which were decreased when cells were treated with NaN02. Peroxynitrite levels were also decreased in NaN02 stressed cells when they were treated with Bael leaf extract. Lipid peroxidation measurement studies were also done using thiobarbituric acid (TBA) which revealed the significant reduction in MDA levels when stressed cells were treated with Bael leaf extract. A significant increase in DPPH radical scavenging activity and Ferric reducing ability was also observed in cells treated with Bael leaf extract which was decreased upon stress induction. Our results strongly support the antioxidant potential of aqueous Bael leaf extract besides acting as a neuroprotective agent which is indicated by an increased levels of antioxidant enzymes which were decreased in NaN02 stressed PC-12 cells.
机译：本研究旨在使用亚硝酸钠应胁迫的PC-12细胞确定凸块叶（Aegle Marmelos）水提取物的抗氧化潜力。干燥的Bael叶的含水提取物显示出抗氧化酶的升高水平，其中当用NaN02处理细胞时降低的超氧化物歧化酶（SOD）和过氧化氢酶。当用Bael叶提取物处理时，纳米硝酸盐水平在NaN02应激细胞中也降低。使用硫氨基吡甲酸（TBA）还完成脂质过氧化测量研究，该硫酸酸（TBA）显示用Bael叶提取物处理应激细胞时MDA水平显着降低。在用Bael叶提取物处理的细胞中，还观察到DPPH激进清除活性和公共减少能力的显着增加，该蛋白叶提取物对应激诱导降低。我们的结果强烈地支持水性膨胀叶提取物的抗氧化剂潜力，除了作为神经保护剂的作用，该抗氧化剂由在纳米-12细胞中降低的抗氧化酶的增加程度表示。

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