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首页> 外文期刊>Acta Radiologica >Simultaneous PET/MR imaging of the brain: feasibility of cerebral blood flow measurements with FAIR-TrueFISP arterial spin labeling MRI.
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Simultaneous PET/MR imaging of the brain: feasibility of cerebral blood flow measurements with FAIR-TrueFISP arterial spin labeling MRI.

机译：大脑同时进行PET / MR成像：使用FAIR-TrueFISP动脉自旋标记MRI测量大脑血流的可行性。

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Background Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) with simultaneous data acquisition promises a comprehensive evaluation of cerebral pathophysiology on a molecular, anatomical, and functional level. Considering the necessary changes to the MR scanner design the feasibility of arterial spin labeling (ASL) is unclear. Purpose To evaluate whether cerebral blood flow imaging with ASL is feasible using a prototype PET/MRI device. Material and Methods ASL imaging of the brain with Flow-sensitive Alternating Inversion Recovery (FAIR) spin preparation and true fast imaging in steady precession (TrueFISP) data readout was performed in eight healthy volunteers sequentially on a prototype PET/MRI and a stand-alone MR scanner with 128 × 128 and 192 × 192 matrix sizes. Cerebral blood flow values for gray matter, signal-to-noise and contrast-to-noise ratios, and relative signal change were compared. Additionally, the feasibility of ASL as part of a clinical hybrid PET/MRI protocol was demonstrated in five patients with intracerebral tumors. Results Blood flow maps showed good delineation of gray and white matter with no discernible artifacts. The mean blood flow values of the eight volunteers on the PET/MR system were 51 ± 9 and 51 ± 7 mL/100 g/min for the 128 × 128 and 192 × 192 matrices (stand-alone MR, 57 ± 2 and 55 ± 5, not significant). The value for signal-to-noise (SNR) was significantly higher for the PET/MRI system using the 192 × 192 matrix size (P < 0.01), the relative signal change (δS) was significantly lower for the 192 × 192 matrix size (P = 0.02). ASL imaging as part of a clinical hybrid PET/MRI protocol could successfully be accomplished in all patients in diagnostic image quality. Conclusion ASL brain imaging is feasible with a prototype hybrid PET/MRI scanner, thus adding to the value of this novel imaging technique.
机译：背景技术同时进行数据采集的混合正电子发射断层扫描/磁共振成像（PET / MRI）有望在分子，解剖学和功能水平上全面评估脑部病理生理。考虑到MR扫描仪设计的必要更改，尚不清楚动脉旋转标记（ASL）的可行性。目的评估使用原型PET / MRI装置进行ASL的脑血流成像是否可行。材料和方法在八名健康志愿者中，依次使用原型PET / MRI和独立设备，对血流交替交替反转恢复（FAIR）旋转准备和稳定进动（TrueFISP）数据进行了真正的快速成像，对大脑进行了ASL成像MR扫描仪具有128×128和192×192矩阵尺寸。比较了脑灰质的血流值，信噪比和对比噪声比以及相对信号变化。此外，在5名脑内肿瘤患者中证明了ASL作为临床PET / MRI混合方案一部分的可行性。结果血流图显示出良好的灰色和白色物质轮廓，没有明显的伪影。对于128×128和192×192矩阵（独立MR，57±2和55），在PET / MR系统上八位志愿者的平均血流值为51±9和51±7 mL / 100 g / min ±5，不显着）。对于使用192×192矩阵尺寸的PET / MRI系统，信噪比（SNR）值明显更高（P <0.01），对于192×192矩阵尺寸的相对信号变化（δS）明显更低（P ＝ 0.02）。作为临床混合PET / MRI方案的一部分，ASL成像可以在所有患者中成功完成诊断图像质量的检查。结论使用原型混合PET / MRI扫描仪进行ASL脑成像是可行的，从而增加了这种新颖的成像技术的价值。

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