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首页> 外文期刊>Acta Radiologica >Bolus compared with continuous infusion of microbubble contrast agent using real-time contrast harmonic imaging ultrasound in breast tumors.
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Bolus compared with continuous infusion of microbubble contrast agent using real-time contrast harmonic imaging ultrasound in breast tumors.

机译：与使用实时对比谐波成像超声在乳腺肿瘤中连续输注微泡造影剂进行比较。

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BACKGROUND: Contrast-enhanced ultrasound (CEUS) has gained interest because of its ability to gather vascular information in various organs. There is still a matter of debate concerning its value in breast lesions. The method of choice on how to administer the contrast agent varies depending on the organ to be studied. Infusion of microbubbles is used in echocardiography, while bolus administration is the preferred technique for abdominal organs. PURPOSE: To compare-in equal doses-bolus versus continuous infusion of microbubbles, using real-time contrast harmonic imaging in breast tumors. MATERIAL AND METHODS: A total of 29 female patients (mean age 54 years) with either clear malignant or benign findings in the breast or axilla were included. Contrast harmonic imaging (CHI US) was performed with a Philips iU22 using an L9-3 MHz linear probe, especially designed for this purpose. A low mechanical index (0.06-0.07) was used to avoid massive destruction of the microbubbles. A dose of 2.4 ml of Sono Vue was first infused intravenously over 1 min with an infusion pump. After 10 min, the same dose was injected as a bolus over 2 s, followed by a flush of 10 ml of saline solution. Contrast uptakes by the tumors were recorded 2 min from the moment of injection, with both methods for each patient. Results: Bolus administration of contrast agent provided a sharply demarcated enhancement and wash-out pattern for all lesions. The continuous infusion of the same contrast agent failed to show any wash-in/wash-out or time-to-peak/peak intensity phenomena in all cases. CONCLUSION: CEUS using real-time harmonic imaging in order to evaluate breast tumors should be performed with bolus administration of contrast agent in order to achieve better intensity/time curve outcomes.
机译：背景：造影增强超声（CEUS）由于能够在各个器官中收集血管信息而引起了人们的兴趣。关于它在乳腺病变中的价值仍有争议。造影剂的选择方法根据所研究的器官而不同。在超声心动图中使用微泡输注，而推注给药是腹部器官的首选技术。目的：使用实时对比谐波成像在乳腺肿瘤中比较等剂量推注与连续输注微泡。材料与方法：包括29名女性患者（平均年龄54岁），其乳房或腋窝有明显的恶性或良性发现。对比谐波成像（CHI US）是使用L9-3 MHz线性探头在Philips iU22上进行的。使用低机械指数（0.06-0.07）避免大量破坏微气泡。首先用输液泵在1分钟内静脉内注入2.4 ml Sono Vue。 10分钟后，在2 s内以大剂量注射相同剂量，然后冲洗10 ml盐水溶液。从注射时刻起2分钟记录肿瘤对造影剂的摄取，对于每位患者使用两种方法。结果：注射造影剂后，所有病变均明显划定了增强和清除模式。在所有情况下，连续注入相同的造影剂均未显示出任何洗入/洗出或达到峰值时间/峰值的现象。结论：CEUS采用实时谐波成像以评估乳腺肿瘤，应与造影剂一起快速推注，以达到更好的强度/时间曲线结果。

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