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首页> 外文期刊>Acta Radiologica >Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: Ventricular fibrillation during left coronary arteriography in pigs.
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Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: Ventricular fibrillation during left coronary arteriography in pigs.

机译：预测新型碘化造影剂GE-145的心脏毒性倾向：猪左冠状动脉造影期间的心室纤颤。

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BACKGROUND: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. PURPOSE: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. MATERIAL AND METHODS: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaC (Visipaque) were injected in six pigs. RESULTS: Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3+/-7.5 s (mean +/- SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P<0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl caused VF in 9 of 9 injections (100%) after 61+/-4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl did not cause any VF during or after 9 injections of each agent (0%) (P<0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl. CONCLUSION: In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium.
机译：背景：碘化造影剂（CM）引起的严重副作用很少见，但可能发生在高危患者和经皮冠状动脉介入治疗期间。为了最大程度地降低这种风险，已设计了一种新的具有低固有渗透压的非离子型CM，为等渗配方中相对较高浓度的有利电解质提供了空间。目的：通过比较其心室纤颤（VF）倾向和血液动力学效应与碘克沙醇的比较，在猪的心脏毒性模型中测试一种新的射线照相CM（GE-145）。材料与方法：通过充气的球囊导管向猪的左冠状动脉前降支（LAD）注射试验药物（注射量25 ml，注射速率0.4 ml / s，最大注射时间62.5 s）。系列1：将GE-145（338 mg I / ml）+ 45 mM NaCl和碘克沙醇（321 mg I / ml）+ 19 mM NaCl注射到五只猪中。系列2：将GE-145（320 mg I / ml）+ 45 mM NaCl + 0.1、0.3或0.7 mM CaCl和碘克沙醇（320 mg I / ml）+ 19 mM NaCl + 0.3 mM CaC（Visipaque）注入六个猪。结果：60.3 +/- 7.5 s（平均+/- SD）后，碘克沙醇+ NaCl在13次注射中有6次（46％）引起VF。 GE-145 + NaCl在13次注射中未引起任何VF（0％）（P <0.05）。碘克沙醇+ 19 mM NaCl + 0.3 mM CaCl在61 +/- 4 s后的9次进样中有9次（100％）引起了VF。 GE-145 + 45 mM NaCl + 0.1、0.3或0.7 mM CaCl在每种试剂（0％）的9次注射期间或之后均未引起VF（P <0.05）。用GE-145 + 45 mM NaCl + 0.7 mM CaCl观察到的血流动力学影响最小。结论：在这种将CM直接施用到麻醉猪的LAD中的模型中，经过测试的GE-145制剂诱导VF的倾向明显低于带有电解质的碘克沙醇。 GE-145的良好血液动力学特性可通过优化钠和钙的浓度来实现。

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