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首页> 外文期刊>Indian journal of pharmacology. >Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin - A prospective, randomized comparative study
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Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin - A prospective, randomized comparative study

机译：口服三萘芬对皮肤病皮肤病感染治疗皮肤病的疗效 - 一种预期，随机对比研究

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OBJECTIVES: Dermatophytic Infections are the common fungal infections aggravated by hot and humid climate. Terbinafine and itraconazole are commonly used oral antifungal agents for the same. However, resistance to these drugs is being seen increasingly when used in the conventional doses and duration. Therefore, this study was designed to compare the efficacy of terbinafine and itraconazole in increased dosages and duration in the treatment of tinea corporis and tinea cruris. MATERIALS AND METHODS: In this randomized comparative study, patients of tinea cruris and tinea corporis were randomly divided into two groups of 160 each and were given oral terbinafine (Group I) and oral itraconazole (Group II) for 4 weeks. The scores and percentage change in scores of pruritus, scaling, and erythema were evaluated at 2 and 4 weeks. RESULTS: At the end of week 4, mycological cure was seen in 91.8% after 4 weeks in the itraconazole group as compared to 74.3% of patients in the terbinafine group. There was a significant improvement in percentage change in pruritus, scaling, and erythema in both the groups from 0 to 4 weeks. On comparing groups, the percentage change was significantly different in scaling from 0 to 2 weeks (5.4 vs. -4.8) and 2-4 weeks (16.7 vs. 29.6) between Group I and Group II, respectively. Clinical global improvement was better with itraconazole. Mild adverse effects such as gastrointestinal upset, headache, and taste disturbances were observed which were comparable in both the groups. CONCLUSIONS: Itraconazole and terbinafine seem to be equally effective and safe in the treatment of tinea cruris and tinea corporis.
机译：目的：皮肤病感染是炎热和潮湿的气候恶化的常见真菌感染。 Terbinafine和Itraconazole通常使用口服抗真菌剂。然而，在常规剂量和持续时间中使用时，越来越多地看到对这些药物的抗性。因此，本研究旨在比较Terbinafine和Itroconazole在治疗Tunea Corcleis和Tunea Cruris的增加剂量和持续时间内的疗效。材料和方法：在该随机对比研究中，Tinea Cruris和Tunea CoriSis的患者随机分为两组，每组160组，并给予口服三萘脒（I）和口服伊唑奈唑（II组）4周。在2和4周评估瘙痒，缩放和红斑的评分分数和百分比变化。结果：在第4周结束时，伊唑康唑组4周后，Mycological Cure在91.8％中被观察到，而Terbinafine Group中的74.3％的患者。从0到4周的群体中瘙痒，缩放和红斑的百分比变化百分比变化显着改善。在比较群体上，分别在0到2周（5.4与-4.8）和第I组和第II组之间的​​2-4周（16.7 vs.29.6）中，缩放百分比变化显着不同。 Itroconazole临床全球改善更好。观察到温和的不良反应，例如胃肠不适，头痛和味道紊乱，在两组中相当。结论：Itraconazole和Terbinafine似乎同样有效和安全地治疗Tinea Cruris和Tinea Corcleis。

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