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首页> 外文期刊>Indian Journal of Small Ruminants >PHARMACOKINETIC IMPLICATIONS OF ALBENDAZOLE BIOTRANSFORMATION IN GOATS FOLLOWING INTERACTION WITH CURCUMA LONGA
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PHARMACOKINETIC IMPLICATIONS OF ALBENDAZOLE BIOTRANSFORMATION IN GOATS FOLLOWING INTERACTION WITH CURCUMA LONGA

机译：与莪术相互作用后山羊阿贝扎唑生物转化的药代动力学影响

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摘要

To test the hypothesis that Curcuma longa could act as hepatic microsomal cytochrome P450 inhibitor resulting in increased bioavailability of albendazole, a study was undertaken to understand the pharmacokinetics and efficacy of albendazole in goats with and without coadministration of albendazole with hydroalcoholic extract of Curcuma longa at 7.5 and 500.0 mg per kg body weight, respectively. The comparative pharmacokinetic values (Mean±S.E.) of albendazole sulphoxide in goats using albendazole and albendazole combination revealed significantly (P<0.05) reduced values of concentration maximum, area under concentration-time curve and total area under the first movement of plasma drug concentration-time curve (P<0.001) in goats receiving albendazole and Curcuma longa. Significantly lower values of under concentration-time curve in goats receiving albendazole in combination with Curcuma longa had resulted in relative bioavailability of 0.57. Estimated drug-parasite contact of albendazole sulphoxidein goats revealed significantly decreased values in goats receiving ABZ combination. Nematode parasites of goats dominated by Haemonchus contortus also exhibited resistant against benzimidazole following administration of albendazole alone and in combination with Curcuma longa. Simultaneous administration of hydroalcoholic extract of Curcuma longa, contrary to the hypothesis, resulted in reduced bioavailability of albendazole.
机译：为了测试Curcuma Longa可以充当肝微粒体细胞色素P450抑制剂，导致阿美唑的生物利用度提高，研究了一项研究，以了解山羊在山羊中阿美唑的药代动力学和疗效，并在7.5时与Curcuma Longa的水醇提取物加入植物醇提取物。分别为每千克体重500.0mg。使用阿仑唑和阿贝唑组合的山羊中阿仑唑硫氧化物的比较药代动力学值（平均±SE）显着显着（P <0.05）降低浓度最大值，浓度 - 时间曲线下的面积和血浆药物浓度的第一次运动下的总面积 - 在山羊接受阿贝扎唑和莪术的时间曲线（p <0.001）。在接受阿比萨唑与姜黄Longa结合接受阿比萨唑的山羊浓度 - 时间曲线的显着较低导致相对生物利用度为0.57。估计的药物 - 寄生虫接触硫氧酰胺山羊在接受ABZ组合的山羊中显着降低。在Haemonchus intortus占据的山羊的Nematode寄生虫也表现出对单独给药并与姜黄Longa组合施用苯并咪唑的抗坏苯并咪唑。同时施用Curcuma Longa的水醇提取物，与假设相反，导致阿贝扎唑的生物利用度降低。

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  • 来源
    《Indian Journal of Small Ruminants》 |2019年第2期|共7页
  • 作者

    S. Nath; P. K. Sanyal; S. Pal;

  • 作者单位

    Department of Veterinary Parasitology College of Veterinary Science and Animal Husbandry Chhattisgarh Kamdhenu Vishwavidyalaya Anjora Durg- 491 001 Chhattisgarh;

    Department of Veterinary Parasitology College of Veterinary Science and Animal Husbandry Chhattisgarh Kamdhenu Vishwavidyalaya Anjora Durg- 491 001 Chhattisgarh;

    Department of Veterinary Parasitology College of Veterinary Science and Animal Husbandry Chhattisgarh Kamdhenu Vishwavidyalaya Anjora Durg- 491 001 Chhattisgarh;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物学;
  • 关键词

    Albendazole; Co-administration; Curcuma longa; Goat; Pharmacokinetics;

    机译：Albendazole;共同给药;姜黄长;山羊;药代动力学;

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