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首页> 外文期刊>Indian journal of physiology and pharmacology >Evaluation of intraperitoneal vincristine in malignant peritoneal effusion.
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Evaluation of intraperitoneal vincristine in malignant peritoneal effusion.

机译：腹膜内血管素对恶性腹膜积液的评价。

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摘要

The efficacy and safety of intraperitoneal administration of vincristine sulphate was determined in mice bearing Ehrlich ascitic carcinoma. The tumor bearing animals were administered with 0.5 mg/kg body weight (b.wt) of freshly prepared vincristine sulphate intraperitoneally on day 6 after tumor transplantation followed by drug administration once daily 5 days a week consecutively. The observations regarding the survival, alteration in the volume of peritoneal fluid, increase in life span and pathological changes in the liver, kidney, gastrointestinal tract and bone tissues were made. The vincristine sulphate treatment reduced the malignant cell population significantly and there were no significant changes in the histological picture of liver, kidney, bone, except the intestine, where atropy of villi demonstrating nests and cords of uniform small round cells were observed. Our experimental data suggests that intraperitoneal administration of vincristine is beneficial in malignant peritoneal effusion.
机译：腹腔硫酸盐尿液施用的疗效和安全性在含有EHRLICH肠癌的小鼠中测定。在肿瘤移植后第6天腹膜内腹膜内携带0.5mg / kg体重（b.wt）的新鲜制备的上升硫酸盐，然后每天每周连续5天。制备了关于存活，腹膜流体体积，生命跨度增加和肝脏，肾，胃肠道和骨组织的病理变化的观察结果。硫酸盐治疗显着降低恶性细胞群，肝脏，肾脏，骨骼的组织学图片没有显着变化，除肠外，观察到绒毛的无休干绒毛和均匀小圆形细胞的绳索。我们的实验数据表明，腹腔内施用血管内的恶性腹膜积液是有益的。

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