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首页> 外文期刊>Indian journal of physiology and pharmacology >Experimental Studies on The Role of Nitric Oxide (NO) in High Altitude Stress Induced Physiological and Behavioral Changes in Rats
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Experimental Studies on The Role of Nitric Oxide (NO) in High Altitude Stress Induced Physiological and Behavioral Changes in Rats

机译：一氧化氮（NO）在高海拔应力诱导大鼠生理和行为变化中的实验研究

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摘要

The present study evaluated the effects of acute high altitude stress induced physiological and neurobehavioral changes and the possible involvement of nitric oxide (NO) in the regulation of such effects in rats. High altitude was simulated in a high altitude/hypoxia chamber and the effects of such stress and its modulation by NO-ergic agents were assessed on plasma corticosterone, anxiety and oxidative stress markers in rats. Acute high altitude stress induced reductions in open arm entries and open arm time in the elevated plus maze (EPM) test-suggestive of anxiety like behavior and was associated with increased levels of plasma corticosterone. Assay of brain homogenates showed lowered levels of NO metabolites (NOx) and GSH but elevated MDA. Pretreatment with the NO-mimetic, L-arginine (500 mg/kg) attenuated, whereas, the NOS inhibitor, L-NAME (50 mg/kg) aggravated both behavioral and biochemical changes induced by such high altitude exposure. Further, when combined with restraint stress (RS), these neurobehavioral and biochemical changes were further accentuated when compared to high altitude per se. Similarly, pretreatment with the L-Arginine neutralized the effects of high altitude + RS, whereas, L-NAME potentiated the behavioral and biochemical effects of the combined stressors. These results suggest that acute high altitude stress induced HPA axis activation, anxiogenesis and oxidative stress which were under the regulatory influence of NO.
机译：本研究评估了急性高海拔应力诱导的生理和神经外伤变化的影响以及一氧化氮（NO）在大鼠这些作用的调节中的可能参与。在高海拔/缺氧室中模拟高海拔，并在大鼠血浆皮质酮，焦虑和氧化应激标志物上评估这种应力及其对NO-ER-ER-ERGIC试剂的影响。急性高海拔应力诱导在高臂条目中减少，在升高的加上迷宫（EPM）测试中的焦虑症（EPM）测试暗示等行为的暗示性，并且与血浆皮质酮水平增加有关。脑匀浆的测定表明没有代谢物（NOx）和GSH的含量降低，但MDA升高。预处理无模拟物，L-精氨酸（500mg / kg）衰减，而NoS抑制剂，L-名称（50mg / kg）加剧了通过这种高空暴露引起的行为和生物化学变化。此外，当与约束应激（RS）结合时，与高海拔地区相比，这些神经饲料和生物化学变化进一步突出。类似地，用L-精氨酸的预处理中和高海拔+卢比的影响，而L-NAME加强了组合压力源的行为和生化效果。这些结果表明，急性高海拔应力诱导的HPA轴激活，焦虑和氧化应激，其在监管影响下。

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