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首页> 外文期刊>Indian journal of physiology and pharmacology >Leptin, Adiponectin and its Molar Ratio as a Biomarker in the Diagnosis of Metabolic Syndrome
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Leptin, Adiponectin and its Molar Ratio as a Biomarker in the Diagnosis of Metabolic Syndrome

机译：Leptin，脂联素及其摩尔比在代谢综合征诊断中的生物标志物

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Background: In order to prevent the downstream effects of metabolic syndrome, it is essential to identify the disease in its early stage and to initiate early treatment. Objective: To analyze the relationship of the adipocyte-derived hormones (adiponectin and leptin) with indices of metabolic syndrome diagnosis in Gujarati adult population. Design and setting: In this cross-sectional study, total 87 consecutive patients (44 metabolic syndrome positive and 43 metabolic syndrome negative) were recruited. Clinical evaluation included anthropometry, blood pressure, serum insulin (by electrochemiluminescence), adiponectin (by ELISA), leptin (by ELISA), and related parameters such as blood pressure, lipids and fasting blood glucose. Presence of the metabolic syndrome was assessed according to the joint statementgiven by international groups (2009). Results: Of the enrolled participants (n: 87), individuals with metabolic syndrome (n: 44) had lower adiponectin, but higher leptin, insulin resistance index and insulin levels than participants with no metabolic syndrome (n: 43). On bivariate correlation analysis with Pearson’s correlation coefficient (r), leptin and adiponectin were positively and negatively linked, respectively, with waist circumference, BMI, triglyceride and fasting insulin. However, with respect to HDL-C, a strong negative and positive correlation (p<0.001) was found between leptin and adiponectin respectively. Leptin/Adiponectin ratio had a largest AUC (0.892) suggesting its better diagnostic utility with 91% sensitivity and 81% specificity in studied population compare to leptin (0.875) and adiponectin (0.684).
机译：背景：为了防止代谢综合征的下游效应，必须在早期阶段鉴定疾病并开始早期治疗。目的：分析姜黄综合征诊断抗脂肪细胞衍生激素（脂联素和瘦蛋白）的关系。设计和环境：在这种横断面研究中，招募了87例连续87名（44例代谢综合征阳性和43种代谢综合征负数）。临床评价包括人体测量术，血压，血清胰岛素（通过电化学荧光），脂联素（通过ELISA），瘦素（通过ELISA），以及血压，脂质和空腹血糖等相关参数。根据国际集团（2009年）的关节评估了代谢综合征的存在。结果：注册参与者（N：87），具有代谢综合征（N：44）的个体具有较低的脂联素，但瘦素，胰岛素抵抗指数和胰岛素水平比与没有代谢综合征的参与者（N：43）。与Pearson相关系数（R）的双变量相关分析，分别具有腰围，BMI，甘油三酯和禁食胰岛素的瘦蛋白和脂联素呈正且呈负连接。然而，关于HDL-C，分别在瘦素和脂联素之间发现强的阴性和正相关（P <0.001）。瘦素/脂联素的比例具有最大的AUC（0.892），表明其具有91％敏感性的更好的诊断效用和研究人群与瘦素（0.875）和脂联素（0.684）进行的81％的特异性。

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