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首页> 外文期刊>Indian journal of physiology and pharmacology >EFFECT OF LESION OF NUCLEUS SEPTAL MEDIALIS ON ENERGY HOMEOSTASIS IN WISTAR RATS.
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EFFECT OF LESION OF NUCLEUS SEPTAL MEDIALIS ON ENERGY HOMEOSTASIS IN WISTAR RATS.

机译：细胞核间隔中间核损伤对Wistar大鼠能量稳态的影响。

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Abstract : Mesolimbic areas such as nucleus accumbens, amygdala and septal nuclei are known to influence food intake and body weight. However, the reports on gender difference in the neural regulation of obesity and energy homeostasis are incomplete. Therefore, the present study was conducted to assess the effect of lesions of nucleus septal medialis (NSM) and the gender difference of lesion on food intake (FI), body weight (BW), serum lipid profile, thyroid profile, glucose and insulin levels and glucose-insulin ratio (GIR) in Wistar albino rats. Twenty-four rats were divided equally into control and experimental groups having 6 male and 6 female rats in each group. In the experimental group, bilateral electrolytic lesion of NSM was performed by stereotaxy and post-lesion parameters were recorded. In the control group, sham-lesions of NSM were produced. Following lesion, blood glucose and serum insulin levels were decreased and GIR was increased significantly in female rats, but not in male rats. It was concluded that NSM is involved in energy homeostasis, especially in female rats.
机译：摘要：已知培核遗传区域，如核心腺，杏仁核和隔膜核，影响食物摄入和体重。但是，肥胖和能源稳态神经调节性别差异的报告是不完整的。因此，对本研究进行了评估核核心子宫子（NSM）病变的影响和病变对食物摄入（FI）的性别差异，体重（BW），血清脂质曲线，甲状腺曲线，葡萄糖和胰岛素水平Wistar白化大鼠的葡萄糖 - 胰岛素比（GIR）。将二十四只大鼠分别分为每组6只雄性和6只雌性大鼠的对照和实验组。在实验组中，NSM的双侧电解病变由立体岩，记录后病变参数进行。在对照组中，产生了NSM的假病变。在病变之后，血糖和血清胰岛素水平降低，雌性大鼠的GIR显着增加，但不在雄性大鼠中增加。结论是NSM参与能量稳态，特别是在女性大鼠中。

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