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首页> 外文期刊>Indian journal of physiology and pharmacology >Rapid Eye Movement (REM) Sleep Deprivation Reduces Pain Perception in Sciatic Nerve-ligated Wistar Rats; Involvement of Muscarinic Autonomic Receptor(s)
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Rapid Eye Movement (REM) Sleep Deprivation Reduces Pain Perception in Sciatic Nerve-ligated Wistar Rats; Involvement of Muscarinic Autonomic Receptor(s)

机译：快速眼球运动（REM）睡眠剥夺降低了坐骨神经连接的Wistar大鼠的疼痛感知; 毒蕈碱自主受体的参与（s）

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Effects of chronic sleep deprivation was investigated in Wistar rats. Forty rats were divided equally into two study groups. Study 1 investigated the effects of REM sleep deprivation (REMSD) on neuropathic pain perception while study 2 investigated the involvement of autonomic receptors on the pain perception following REMSD. Chronic constriction injury (CCI) of the sciatic nerve was used to induce neuropathic pain and multiple platform method for the induction of REMSD. The results of the test group showed a significant (p<0.05) increase in the mean reaction time (hot plate test) to thermal hyperalgesia. Also, there was a significant (p<0.05) increase in tail withdrawal latency (tail immersion tests) in test group. Various autonomic receptor antagonists were administered in study 2 to investigate their possible involvement in the observed analgesic effect of REMSD. Both atropine and propranolol produced an increase in pain perception thus, abolishing the anti-nociceptive effect of REMSD on neuropathic pain but the effect of atropine was more pronounced. From this, it appears that atropine; a muscarinic receptor blocker has the maximum capacity to reverse the analgesic effect of REMSD on neuropathic pain thus, suggesting the involvement of muscarinic cholinergic system. From these results, we hypothesize that REMSD has hypoalgesic effect on neuropathic pain which is modulated by muscarinic-cholinergic receptor.
机译：Wistar大鼠研究了慢性睡眠剥夺的影响。四十只大鼠同样分为两种研究组。研究1研究了REM睡眠剥夺（REMSD）对神经病疼痛感知的影响，而研究2调查了自主受体对REMSD后疼痛感知的影响。坐骨神经的慢性收缩损伤（CCI）用于诱导诱导Remsd的神经性疼痛和多平台方法。测试组的结果显示出对热痛觉过敏的平均反应时间（热板试验）增加（P <0.05）。此外，试验组中的尾抽出潜伏期（尾浸渍试验）增加了显着（P <0.05）。在研究2中施用各种自主主义受体拮抗剂，以研究其可能参与检测的镇痛作用。阿托品和普萘洛尔均产生疼痛感知的增加，因此，废除了Remsd对神经性疼痛的抗伤害作用，但阿托嘌呤的作用更加明显。从这里，似乎阿托品;肌肉蛋白受体阻滞剂具有最大的能力，以逆转Remsd对神经性疼痛的镇痛作用，因此表明毒蕈碱胆碱能系统的参与。从这些结果中，我们假设Remsd对肌肉胆碱能受体调节的神经性疼痛具有高扶诊作用。

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