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首页> 外文期刊>Indian journal of physiology and pharmacology >Regulation of lonotropic Glutamatergic Mechanisms Following Treatment with Chlorpromazine
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Regulation of lonotropic Glutamatergic Mechanisms Following Treatment with Chlorpromazine

机译：用氯丙嗪处理后孤独的谷氨酸胶质剂机制的调节

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Objective: Chlorpromazine hydrochloride (CPZ) refers to antipsychotic drugs. CPZ is drug of first choice for the treatment of schizophrenia. Currently interaction CPZ with dopamine receptors is the dominant view. However, its impact on the main excitatory neurotransmitter system, glutamatergic, is unclear. This issue is the aim of our study. Methods: Experiments carried out on brain slices of the olfactory cortex of rats. We used electrophysiological techniques extracellular recordings in brain slice to investigate CPZ effects on the activity of the both glutamatergic ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptors (AMPARs) and N-methyl-D-aspartic acid type glutamate receptors (NMDARs). Results: Application of CPZ on slices modified the incoming and outgoing sodium potassium currents involved in the generation of AMPA EPSP (excitatory postsynaptic potential). CPZ nonlinear way modified AMPARs activity with increasing concentrations. Opposite, NMDARs activity decreased in a linear manner with increasing concentrations CPZ. The neuroleptic actively interacted with glutamate and glycine sites of NMDARs. To specify of CPZ neurotrophic effects promazine, which is structurally similar to CPZ, was applicated on slices. Promazine did not caused significant modifications of the activity both AMPARs and NMDARs. In order to improve functions of NMDARs slices pretreated by ammonium chloride (NH_4CI, 20 mM), which is commonly recognized as fast and efficient lysosomal inhibitor. Such processing slices and subsequent action of CPZ protected the functioning of NMDARs. Conclusions: Data presented in this study on the influence of CPZ on the ionotropic glutamatergic mechanisms allow to understand the multifaceted mechanisms action of neuroleptic in protection against deterioration of mental disorders such as schizophrenia.
机译：目的：盐酸氯丙嗪（CPZ）是指抗精神病药物。 CPZ是治疗精神分裂症的首选药物。目前与多巴胺受体的相互作用CPZ是主导视图。然而，它对主要兴奋性神经递质系统的影响尚不清楚。这个问题是我们研究的目的。方法：对大鼠嗅觉皮层的脑切片进行实验。我们使用了脑切片中的电生理技术细胞外记录来研究CPZ对谷氨酸间离子型α-氨基-3-羟基-5-甲基-4异恶唑的活性的影响谷氨酸受体（NMDARS）。结果：CPZ在切片上的应用修改了AMPA EPSP（兴奋性突触潜力）的发电中涉及的入境和传出钠钾电流。 CPZ非线性方式改进了浓度增加的AMPARS活动。相反，NMDARS活性以线性方式随着浓度CPZ的增加而降低。作者指定CPZ神经营养效应普促在结构上与CPZ相似的Promazine进行了应用。 Promazine没有造成AMPAR和NMDARS的活动的重大修改。为了改善由氯化铵（NH_4CI，20mM）预处理的NMDARS切片的功能，其通常被认为是快速高效的溶酶体抑制剂。 CPZ的这种处理切片和随后的动作受到NMDAR的运作。结论：本研究提出的数据对CPZ对离子淋谷氨酸机制的影响，允许了解神经抑制的多方面机制，防止精神障碍等精神病患者的恶化。

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