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首页> 外文期刊>Acta Radiologica >Discriminative analysis of early-stage Alzheimer's disease and normal aging with automatic segmentation technique in subcortical gray matter structures: a multicenter f'n vivo MRI volumetric and DTI study
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Discriminative analysis of early-stage Alzheimer's disease and normal aging with automatic segmentation technique in subcortical gray matter structures: a multicenter f'n vivo MRI volumetric and DTI study

机译：利用自动分割技术对皮层下灰质结构进行早期阿尔茨海默氏病和正常衰老的判别分析：多中心f'n vivo MRI容积法和DTI研究

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Background: Previous studies have revealed that amyloid depositions exist in not only the hippocampus but in other subcortical gray matter structures as well. Diffusion-tensor imaging (DTI) parameters might be more sensitive measures of early degeneration in Alzheimer's disease (AD) than conventional magnetic resonance imaging (MRI) techniques. Purpose: To evaluate the significance of the volumes and the mean diffusivity (MD) values of subcortical gray matter structures in discrimination between early-stage AD and normal subjects using the Integrated Registration and Segmentation Tool in FMRIB's Software Library. Material and Methods: Fifty-three cases of early-stage AD and 30 normal aging volunteers from two hospitals were scanned with 3D-FSPGRIR and SSSE-EPI sequences using two similar I.5T MR systems. The mean relative volumes and mean MD values of subcortical gray matter structures were compared between early-stage AD and control groups. Binary logistic regression analysis and receiver-operating characteristic (ROC) curves were applied to assess the diagnostic significance of every structure's relative volume, MD value, and combination of both. Results: The relative volumes of the left hippocampus, right amygdala, bilateral thalamus, right caudate, left putamen, and bilateral pallidum were significantly lower in the early-stage AD group than in the control group (P<0.05). The MD values of the bilateral hippocampus and pallidum, and of the right thalamus and caudate were significantly elevated in the early-stage AD group (P < 0.05). In binary logistic regression analysis, the relative volume of left hippocampus and age entered the final model of volumetric analysis. The MD values of bilateral hippocampi and pallidums entered the final model of MD analysis. The MD values of bilateral hippocampi and pallidums, and the relative volume of left pallidum, entered the final model of combination analysis. The accuracy of three models was 84.7%, 88.9%, and 93.1%, respectively. Conclusion: Pathological changes takes place in the hippocampus and other subcortical gray matter structures in early-stage AD. Diffusive imaging has great diagnostic significance in early-stage AD. The combination of both imaging modalities can lead to better discrimination between early-stage AD and normal aging.
机译：背景：以前的研究表明，淀粉样蛋白沉积不仅存在于海马体中，而且也存在于其他皮质下灰质结构中。扩散张量成像（DTI）参数可能是阿尔茨海默氏病（AD）早期变性的更敏感指标，比常规磁共振成像（MRI）技术更敏感。目的：使用FMRIB软件库中的集成配准和分段工具，评估皮层下灰质结构的体积和平均弥散性（MD）值在区分早期AD和正常受试者方面的意义。材料和方法：使用两个类似的I.5T MR系统，对3例早期AD患者和30例来自两家医院的正常衰老志愿者进行了3D-FSPGRIR和SSSE-EPI序列扫描。比较早期AD组和对照组的皮层下灰质结构的平均相对体积和MD平均值。二元逻辑回归分析和接收者操作特征（ROC）曲线用于评估每个结构的相对体积，MD值以及两者的组合的诊断意义。结果：早期AD组左海马，右杏仁核，双侧丘脑，右尾状，左壳核和双侧苍白球的相对体积明显低于对照组（P <0.05）。在早期AD组中，双侧海马和苍白球以及右丘脑和尾状肌的MD值显着升高（P <0.05）。在二元逻辑回归分析中，左海马的相对体积和年龄进入了体积分析的最终模型。双侧海马和苍白的MD值进入了MD分析的最终模型。双侧海马和苍白球的MD值，以及左苍白球的相对体积，成为组合分析的最终模型。三种模型的准确性分别为84.7％，88.9％和93.1％。结论：AD早期海马和其他皮质下灰质结构发生病理变化。漫射成像对早期AD具有重要的诊断意义。两种成像方式的结合可以更好地区分早期AD和正常衰老。

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