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首页> 外文期刊>Infection >Tuberculosis-associated hemophagocytic lymphohistiocytosis with subsequent unmasking cryptococcal immune reconstitution inflammatory syndrome (IRIS) in an HIV-negative man
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Tuberculosis-associated hemophagocytic lymphohistiocytosis with subsequent unmasking cryptococcal immune reconstitution inflammatory syndrome (IRIS) in an HIV-negative man

机译：结核病相关的血糖淋巴管肾小球菌，随后未掩蔽的隐球菌免疫重建炎症综合征（鸢尾）

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摘要

A 22-year-old HIV-negative man from Ghana was diagnosed with severe hemophagocytic lymphohistiocytosis (HLH) induced by multiorgan tuberculosis with peritoneal, hepatic, pericardial, myocardial, pleural, pulmonary, and bone manifestation. His body mass index was 12.9 m(2)/kg. Bioptic material of a peritoneal biopsy grew M. tuberculosis, sensitive to all first-line antituberculous drugs. HLH resolved with antituberculous therapy, without additional anti-inflammatory therapy being given. The initial CT scan of his brain was normal. After 5 months of antituberculous treatment, he developed a paralysis of the left arm. A cerebral MRT showed ring-enhanced lesions. Blood cultures and lumbar puncture revealed Cryptococcus neoformans var. grubi. The HIV test was repeatedly negative. Antituberculous treatment was continued for a total of 9 months, and additional treatment with antifungal therapy was established. He recovered fully after 14 months of antifungal treatment.
机译：来自加纳的22岁的艾滋病毒阴性人被诊断出患有由腹膜，肝癌，心包，心肌，胸膜，肺癌和骨骼表现诱导的严重血糖淋巴管症（HLH）。 他的体重指数为12.9米（2）/千克。 腹膜活组织检查的生物材料致肺结核，对所有第一线抗核酸药物敏感。 HLH解决了抗抑郁疗法，没有额外的抗炎治疗。 他大脑的最初CT扫描正常。 经过5个月的抗劝阻治疗后，他开发了左臂的麻痹。 脑MRT显示出环增强病变。 血液培养和腰椎穿刺揭示了Cryptococcus neoformans var。 Grubi。 HIV测试重复为阴性。 抗胆管治疗总共9个月，并建立了抗真菌治疗的额外治疗。 他在14个月的抗真菌治疗后完全恢复。

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