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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population
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Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population

机译：来自胃癌和十二指肠溃疡患者的HLA-A，HLA-B，HLA-DR和DQ基因多态性与CAGA阳性幽门螺杆菌菌株中的CAGL之间的多态性：在土耳其人群中的第一研究

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摘要

Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical association of the cagL gene with host HLA alleles in H. pylori strains that were isolated from patients with gastric cancer, DU, and non-ulcer dyspepsia (NUD) and to determine the HLA allele that confers susceptibility or resistance for the risk of gastric cancer and DU development in Turkish patients.
机译：H. Pylori的人胃粘膜的定植可能导致消化和十二指肠溃疡（DUS），胃淋巴瘤和胃癌。 CAGL基因是CAG T4SS的组成部分，并参与CAGA易位转移到宿主中。 在不同群体中提出了胃癌风险与HLA II类（DR和/或DQ）之间的关联。 本研究的目的是探讨CAGL基因与H.幽门螺杆菌菌株中宿主HLA等位基因的临床关联，这些菌株与胃癌，DU和非溃疡性消化患者（NUD）分离出来并确定HLA等位基因 赋予土耳其患者胃癌和DU发展风险的易感性或抗性。

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