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首页> 外文期刊>Inflammatory bowel diseases >Real-time Endoscopy-Guided Measurement of Rectal Mucosal Admittance Is a Novel and Safe Method for Predicting Ulcerative Colitis Relapse.
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Real-time Endoscopy-Guided Measurement of Rectal Mucosal Admittance Is a Novel and Safe Method for Predicting Ulcerative Colitis Relapse.

机译：直肠粘膜导煤的实时内窥镜引导测量是一种预测溃疡性结肠炎复发的新颖和安全方法。

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摘要

There are known associations between inflammatory bowel disease (IBD) and changes in mucosal paracellular permeability. We recently developed a novel catheter that can measure mucosal admittance (MA). Patients with ulcerative colitis (UC) in clinical remission underwent real-time MA measurement during colonoscopy between June 2014 and July 2015 and were prospectively followed. MA measures were taken from normal-appearing mucosa using the Tissue Conductance Meter (TCM). We examined relationships between mucosal admittance, clinical parameters at the time of MA measurement, and disease relapse during the follow-up period using the Cox proportional hazards model. We measured baseline MA in 54 patients with UC during remission, with no complications. Of these, 23 patients relapsed during the subsequent follow-up period, at a median of 25.8 ± 7.6 months. Rectal MA was the only predictor of disease relapse in multivariate analysis (P = 0.027). The optimal rectal MA cutoff value for relapse was 781.0 (area under the receiver operating characteristic curve, 0.712), and in patients who showed lower than normal cutoff values, there was a significantly higher likelihood of relapse compared with other patients (log-rank test, P < 0.001). High rectal MA measured by TCM is associated with long-term sustained remission. Real-time rectal MA measurement using a novel endoscopy-guided catheter could be a safe and useful means of predicting prognosis for patients with UC in remission.
机译：炎性肠病（IBD）之间存在已知的关联，以及粘膜阴茎渗透性的变化。我们最近开发了一种可以测量粘膜导纳（MA）的新型导管。患者溃疡性结肠炎（UC）在2014年6月至2015年6月至2015年7月期间在结肠镜检查期间进行了临床缓解的实时MA测量，并进行了前瞻性。使用组织电导计（TCM）从正常出现的粘液中取出MA测量。我们在使用Cox比例危险模型的后续期间检查了MA测量时的粘膜导纳，临床参数的关系，疾病复发。在缓解期间，我们在54例UC患者中测量了基线MA，没有并发症。其中，23名患者在随后的后续期间复发，位于25.8±7.6个月的中位数。直肠MA是多变量分析中疾病复发的唯一预测因子​​（P = 0.027）。复发的最佳直肠MA截止值为781.0（接收器下的区域，操作特征曲线为0.712），并且在显示低于正常截止值的患者中，与其他患者相比，复发的可能性显着更高（对数级测试，p <0.001）。通过TCM测量的高直肠MA与长期持续缓解相关。使用新型内窥镜检查导管使用新型内窥镜导管的实时直肠测量可能是预测UC缓解患者预后的安全和有用的手段。

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  • 来源
    《Inflammatory bowel diseases》 |2018年第11期|共6页
  • 作者

    Takashi Taida; Makoto Arai; Mai Fujie; Naoki Akizue; Kentaro Ishikawa; Yuki Ohta; Shinsaku Hamanaka; Hideaki Ishigami; Kenichiro Okimoto; Keiko Saito; Daisuke Maruoka; Tomoaki Matsumura; Tomoo Nakagawa; Tatsuro Katsuno; Naoya Kato;

  • 作者单位

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Clinical Engineering Center Chiba University Hospital Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

    Kashiwanoha Clinic of East Asian Medicine Chiba University Chiba Japan;

    Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan;

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  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
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