...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Inflammopharmacology >Hydrolysable tannin-rich fraction from Terminalia chebula Retz. fruits ameliorates collagen-induced arthritis in BALB/c mice
【24h】

Hydrolysable tannin-rich fraction from Terminalia chebula Retz. fruits ameliorates collagen-induced arthritis in BALB/c mice

机译：恒定的Chebula Retz中富含水解的单宁富分数。 水果在Balb / C小鼠中改善胶原蛋白诱导的关节炎

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Terminalia chebula Retz. (Fam: Combretaceae) (TC) is widely used in traditional system for the treatment of fever, asthma, urinary diseases, and rheumatism. The aim of the present study is to evaluate the efficacy of hydrolysable tannin-rich fraction (HTF) isolated from TC fruits in collagen-induced arthritic BALB/c mice. Type II collagen-induced arthritis was attained in BALB/c mice. HTF treatment at three gradual doses (100, 200, and 400 mg/kg) was started from 24th day on daily administration up to 4 weeks. Body weight, food intake, and increase in hind paw were monitored at weekly basis. At the end of the study, serum and joint tissues were estimated for proinflammatory cytokines and biochemical parameters and the hind limbs were removed for radiological and histopathological evaluations. Oral administration of HTF could significantly protect CIA in BALB/c mice by reducing paw volume, arthritic score, spleen index, serum and joint cytokine level, and biochemical markers. The anti-inflammatory efficacy of HTF was further demonstrated by morphological observation, histopathological , and radiological evaluations. HTF is a good therapeutic agent for the treatment of joint inflammatory condition, as its action is mediated through cytokine inhibition.
机译：恒星跳蚤·克拉。 （FAM：Combretaceae）（TC）广泛用于传统系统，用于治疗发烧，哮喘，尿疾病和风湿病。本研究的目的是评估从胶原诱导的关节炎BALB / C小鼠中从TC果实中分离的可水解的单宁富分数（HTF）的疗效。 BALB / C小鼠中达到II型胶原蛋白诱导的关节炎。 HTF治疗在三个渐变剂量（100,200和400mg / kg），从24天开始，每日施用长达4周。每周监测体重，食物摄入和后爪的增加。在研究结束时，估计血清和关节组织用于促炎细胞因子和生化参数，除去后肢以进行放射学和组织病理学评估。通过减少爪体积，关节炎评分，脾脏指数，血清和关节细胞因子水平和生化标志物，HTF的口服施用在Balb / C小鼠中可以显着保护CIA。通过形态学观察，组织病理学和放射性评估进一步证明了HTF的抗炎效能。 HTF是一种良好的治疗剂，用于治疗关节炎症病症，因为其作用通过细胞因子抑制介导。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号