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首页> 外文期刊>Acta Radiologica >Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer.
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Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer.

机译：不同组织病理学类型乳腺癌的超声造影结果。

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Background The new application of contrast-enhanced ultrasonography (CEUS) in the diagnosis of breast masses has evolved quickly only in recent years. Nevertheless, mixed results owing to the overlap in characteristics of benign and malignant lesions are simultaneously discovered by most studies, partially attributed to different histopathologic characteristics of breast cancer. Purpose To explore the characteristics of different histopathologic types of breast cancer at real-time gray-scale CEUS and evaluate its diagnostic value. Material and Methods One hundred and one histopathologically confirmed malignant lesions were included. We retrospectively reviewed the contrast-enhanced ultrasonographic findings including morphologic features, quantitative parameters, and correlated them with histopathology. True-positive rate was calculated to assess the diagnostic performance of CEUS. Results The 101 malignancies displayed irregular shape (72 [71%]), poorly-defined margin (73 [72%]), penetrating or tortuous surrounding vessels (79 [78%]), heterogeneous enhancement (84 [83%]), including focal perfusion defects (24 [24%]). For each histopathologic type, 87% (58/67) of invasive ductal carcinoma (IDC) showed heterogeneous enhancement. Of all the 24 perfusion defects, IDC account for 88% (21/24). Low average peak intensity (PI) of 4.9 was detected in this type. Ductal carcinoma in situ (DCIS) excellently showed the features of irregular shape (82% [14/17]), poorly-defined margin (82% [14/17]), heterogeneous enhancement (94% [16/17]). While 83% (5/6) of medullary carcinoma exhibited regular shape, well-defined margin, homogenous enhancement, and high average PI value of 9.6. Invasive lobular carcinoma showed similar enhancement pattern to that of IDC. Intraductal papillary carcinoma displayed high average PI value of 8.1. The overall true-positive rate for conventional US and CEUS was 88%, 86%, respectively. DCIS, medullary carcinoma, and intraductal papillary carcinoma achieved an improved true-positive rate (94%, 100% and 100%, respectively). Conclusion The imaging characteristics of CEUS are variable in different histopathologic types of breast cancer. CEUS does not appear to be superior to conventional ultrasound as a diagnostic tool overall, however, it is a useful adjunct to conventional ultrasound in diagnosing some special types of breast cancer.
机译：背景技术超声造影技术（CEUS）在乳腺肿块诊断中的新应用直到最近才发展迅速。然而，大多数研究同时发现了由于良性和恶性病变特征重叠而导致的混合结果，部分归因于乳腺癌的不同组织病理学特征。目的探讨实时灰度CEUS对不同病理类型乳腺癌的特征，并评价其诊断价值。材料与方法包括一百零一经组织病理学证实的恶性病变。我们回顾性地回顾了超声造影结果，包括形态学特征，定量参数，并将其与组织病理学相关联。计算真实阳性率以评估CEUS的诊断性能。结果101例恶性肿瘤呈不规则形状（72 [71％]），边缘模糊不清（73 [72％]），周围血管穿透或曲折（79 [78％]），异质性增强（84 [83％]），包括局灶性灌注缺陷（24 [24％]）。对于每种组织病理学类型，浸润性导管癌（IDC）的87％（58/67）显示出异质性增强。在所有24个灌注缺陷中，IDC占88％（21/24）。在这种类型中检测到的平均峰强度（PI）低，为4.9。原位导管癌（DCIS）表现出不规则形状（82％[14/17]），边界不清（82％[14/17]），异质性增强（94％[16/17]）。而83％（5/6）的髓样癌表现出规则的形状，清晰的边缘，均一的增强和平均9.6的高PI值。侵袭性小叶癌表现出与IDC相似的增强模式。导管内乳头状癌的平均PI值较高，为8.1。常规美国和CEUS的总真实阳性率分别为88％和86％。 DCIS，髓样癌和导管内乳头状癌的真阳性率提高（分别为94％，100％和100％）。结论CEUS的影像学特征在不同的病理组织学类型的乳腺癌中是不同的。总体而言，CEUS似乎并没有优于常规超声作为诊断工具，但它在诊断某些特殊类型的乳腺癌方面是常规超声的有用辅助手段。

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