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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects
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Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects

机译:外阴阴道念珠菌感染:发病机理,免疫力和疫苗前景

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摘要

Although a number of fungal species belonging to the genus Candida can cause acute vulvovaginal infection (VVC), Candida albicans is by far the most prevalent etiological agent, particularly for the most severe chronic condition known as recurrent vulvovaginal candidiasis (RVVC). This review focuses on recent advances in pathogenic mechanisms and host immune responses to C.albicans and on the utilisation of this information in the development of a vaccine to prevent and/or treat vaginal candidiasis. Currently, two vaccines with main or sole RVVC as clinical indication have completed a phase 1 clinical trial, and one of them has entered a phase 2 trial.
机译:尽管属于念珠菌属的许多真菌物种均可引起急性外阴阴道感染(VVC),但白色念珠菌是最普遍的病原体,尤其是对于最严重的慢性病(称为复发性外阴念珠菌病(RVVC))。这篇综述集中在致病机理和宿主对白色念珠菌的免疫反应方面的最新进展,以及在开发预防和/或治疗阴道念珠菌病的疫苗中利用这些信息。目前,有两种以主要或唯一RVVC为临床指征的疫苗已完成1期临床试验,其中一种已进入2期试验。

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