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Regulation of lung immunity by dendritic cells: Implications for asthma, chronic obstructive pulmonary disease and infectious disease

机译：树突细胞肺免疫调节：对哮喘，慢性阻塞性肺病和传染病的影响

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Since the first description of dendritic cells by Steinman and Cohn in 1973, this important cell type has gained increasing attention. Over 4000 papers have been published on this topic annually during the last few years. At the beginning, dendritic cells were recognized for their immune stimulatory properties and their importance in initiating an adaptive immune response. Later, it was found that dendritic cells do not only initiate but also regulate immune responses. This attribute makes the so-called regulatory dendritic cells highly important for the prevention of exaggerated immune responses. Immune cells make contact with different Ags every day and must be tightly controlled to prevent excessive inflammation and subsequent organ destruction, particularly in organs such as the gut and lungs. Here, we give a brief overview of our current knowledge on how immune responses are controlled by dendritic cells, highlighting how they are involved in the induction of peripheral tolerance. We focus on what is known about these processes in the lung, with a closer look at their role in the induction and control of diseases such as bronchial asthma, chronic obstructive pulmonary disease and lung infections. Finally, we summarize some current approaches to modulate the behavior of dendritic cells that may hopefully lead to future therapeutics to control exaggerated immune responses.
机译：由于1973年Steinman和Cohn的树突细胞的第一次描述，这一重要细胞类型已经提高了越来越关注。在过去几年中，每年在本主题上发表超过4000篇论文。在开始时，识别树突细胞用于其免疫刺激性质及其重要性，以启动适应性免疫应答。后来，发现树突细胞不仅引发而且调节免疫应答。该属性使所谓的监管性树突细胞对预防夸张的免疫反应非常重要。免疫细胞每天与不同的年龄接触，必须紧密控制以防止过量的炎症和随后的器官破坏，特别是在肠道和肺等器官中。在这里，我们简要概述了我们目前关于免疫反应如何由树突细胞控制的知识，突出显示它们如何参与外周耐受性。我们专注于对肺中这些过程所知的内容，仔细观察它们在诱导和控制疾病中的作用，如支气管哮喘，慢性阻塞性肺病和肺部感染。最后，我们总结了一些目前的方法来调节树突状细胞的行为，这些方法可能有希望导致未来治疗剂控制夸张的免疫应答。

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